Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11

• Published in: Cancer research (Chicago, Ill.) Vol. 81; no. 20; pp. 5217 - 5229
• Main Authors: Wang, Xinbo, Chen, Yueqing, Wang, Xudong, Tian, Hongling, Wang, Yanjin, Jin, Jiali, Shan, Zezhi, Liu, Yu'e, Cai, Zhenyu, Tong, Xinyuan, Luan, Yi, Tan, Xiao, Luan, Bing, Ge, Xin, Ji, Hongbin, Jiang, Xuejun, Wang, Ping
• Format: Journal Article
• Language: English
• Published: United States 15.10.2021
• Subjects: Amino Acid Transport System y+ - genetics; Amino Acid Transport System y+ - metabolism; Animals; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell Proliferation; Ferroptosis; Gene Expression Regulation, Neoplastic; Humans; Lipid Peroxidation; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Mice; Mutation; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Prognosis; SOXB1 Transcription Factors - genetics; SOXB1 Transcription Factors - metabolism; Survival Rate; Transcriptional Activation; Tumor Cells, Cultured

Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such therapeutic strategies show limited efficacy due to drug resistance and other largely unknown underlying mech...