From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis

is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review...

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Published inMicroorganisms (Basel) Vol. 9; no. 3; p. 628
Main Authors Rozas, Miquel, Hart de Ruijter, Astrid, Fabrega, Maria Jose, Zorgani, Amine, Guell, Marc, Paetzold, Bernhard, Brillet, Francois
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 18.03.2021
MDPI AG
Subjects
Cutibacterium acnes
microbiome dysbiosis
Review
skin disorders
skin microbiota
topical bacteriotherapy
skin microbiota
Cutibacterium acnes
topical bacteriotherapy
microbiome dysbiosis
skin disorders
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Abstract is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review focused on (i) the abundance of in the skin microbiome of healthy skin and skin disorders, (ii) its major contributions to human skin health, and (iii) skin commensals used as probiotics to alleviate skin disorders. The loss of relative abundance and/or clonal diversity is frequently associated with skin disorders such as acne, atopic dermatitis, rosacea, and psoriasis. , and the diversity of its clonal population, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation. Compared to gut probiotics, limited dermatological studies have investigated skin probiotics with skin commensal strains, highlighting their unexplored potential.
AbstractList Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review focused on (i) the abundance of C. acnes in the skin microbiome of healthy skin and skin disorders, (ii) its major contributions to human skin health, and (iii) skin commensals used as probiotics to alleviate skin disorders. The loss of C. acnes relative abundance and/or clonal diversity is frequently associated with skin disorders such as acne, atopic dermatitis, rosacea, and psoriasis. C. acnes, and the diversity of its clonal population, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation. Compared to gut probiotics, limited dermatological studies have investigated skin probiotics with skin commensal strains, highlighting their unexplored potential.
Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review focused on (i) the abundance of C. acnes in the skin microbiome of healthy skin and skin disorders, (ii) its major contributions to human skin health, and (iii) skin commensals used as probiotics to alleviate skin disorders. The loss of C. acnes relative abundance and/or clonal diversity is frequently associated with skin disorders such as acne, atopic dermatitis, rosacea, and psoriasis. C. acnes , and the diversity of its clonal population, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation. Compared to gut probiotics, limited dermatological studies have investigated skin probiotics with skin commensal strains, highlighting their unexplored potential.
is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review focused on (i) the abundance of in the skin microbiome of healthy skin and skin disorders, (ii) its major contributions to human skin health, and (iii) skin commensals used as probiotics to alleviate skin disorders. The loss of relative abundance and/or clonal diversity is frequently associated with skin disorders such as acne, atopic dermatitis, rosacea, and psoriasis. , and the diversity of its clonal population, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation. Compared to gut probiotics, limited dermatological studies have investigated skin probiotics with skin commensal strains, highlighting their unexplored potential.
Author Rozas, Miquel
Hart de Ruijter, Astrid
Paetzold, Bernhard
Fabrega, Maria Jose
Guell, Marc
Zorgani, Amine
Brillet, Francois
AuthorAffiliation 2 Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), C. Dr. Aiguader 88, 08003 Barcelona, Spain; maria-jose.fabrega@upf.edu
1 S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium; miquel@sbiomedic.com (M.R.); astrid@sbiomedic.com (A.H.d.R.); amine@sbiomedic.com (A.Z.); marc.guell@upf.edu (M.G.); bernhard.paetzold@sbiomedic.com (B.P.)
AuthorAffiliation_xml – name: 2 Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), C. Dr. Aiguader 88, 08003 Barcelona, Spain; maria-jose.fabrega@upf.edu
– name: 1 S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium; miquel@sbiomedic.com (M.R.); astrid@sbiomedic.com (A.H.d.R.); amine@sbiomedic.com (A.Z.); marc.guell@upf.edu (M.G.); bernhard.paetzold@sbiomedic.com (B.P.)
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  organization: Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), C. Dr. Aiguader 88, 08003 Barcelona, Spain
– sequence: 2
  givenname: Astrid
  orcidid: 0000-0001-7278-2580
  surname: Hart de Ruijter
  fullname: Hart de Ruijter, Astrid
  organization: S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium
– sequence: 3
  givenname: Maria Jose
  surname: Fabrega
  fullname: Fabrega, Maria Jose
  organization: Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), C. Dr. Aiguader 88, 08003 Barcelona, Spain
– sequence: 4
  givenname: Amine
  surname: Zorgani
  fullname: Zorgani, Amine
  organization: S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium
– sequence: 5
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  orcidid: 0000-0003-4000-7912
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– sequence: 6
  givenname: Bernhard
  surname: Paetzold
  fullname: Paetzold, Bernhard
  organization: S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium
– sequence: 7
  givenname: Francois
  orcidid: 0000-0003-2759-4139
  surname: Brillet
  fullname: Brillet, Francois
  organization: S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33803499$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords skin microbiota
Cutibacterium acnes
topical bacteriotherapy
microbiome dysbiosis
skin disorders
Language English
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Snippet is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific...
Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted...
Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted...
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SubjectTerms Cutibacterium acnes
microbiome dysbiosis
Review
skin disorders
skin microbiota
topical bacteriotherapy
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Title From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis
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