Perinatal outcomes in euploid pregnancies with ‘double-positive’ first trimester prenatal screening for trisomy 18 and 21

• Published in: Journal of perinatology Vol. 33; no. 11; pp. 836 - 840
• Main Authors: Yee, L M, Valderramos, S G, Pena, S, Cheng, Y W, Bianco, K
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2013; Nature Publishing Group
• Subjects: 692/420/2489/1381/1286; 692/700/139/1512; 692/700/1720; Abnormalities; Adult; Amniocentesis; Aneuploidy; Anomalies; Birth weight; Chi-square test; Chromosomes, Human, Pair 18; Cohort analysis; Cohort Studies; Down syndrome; Down Syndrome - diagnosis; False Positive Reactions; Female; Fetuses; Genetic Testing; Gestational age; Gynecology; Humans; Karyotypes; Karyotyping; Medical screening; Medicine; Medicine & Public Health; Methods; Obstetrics; original-article; Pediatric Surgery; Pediatrics; Ploidies; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Pregnancy, Complications of; Premature birth; Prenatal Diagnosis; Retrospective Studies; Risk factors; Screening; Statistical analysis; Statistical tests; Testing; Trisomy; Trisomy - diagnosis; Trisomy 18 Syndrome; Ultrasonography, Prenatal; Womens health; United States > US; San Francisco California; California; ultrasound abnormalities; nuchal translucency; aneuploidy screening; first trimester screening; false-positive screening

Objective: The objective of this study was to investigate whether women who screened positive for both trisomy 18 (T18) and trisomy 21 (T21) yet had euploid karyotypes were at increased risk for adverse pregnancy outcomes. Study Design: This was a retrospective cohort study of women who had first tr...