Inclusion Complexes of Ethanamizuril with β- and Hydroxypropyl-β-Cyclodextrin in Aqueous Solution and in Solid State: A Comparison Study

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 10; p. 2164
• Main Authors: Guo, Juan, Zhang, Lifang, Wang, Mi, Liu, Yingchun, Fei, Chenzhong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Benzene; Computer simulation; Cyclodextrins; Dextrins; Drinking water; Drugs; Ethanamizuril; Hydrocarbons; Hydrogen; Hydrogen bonding; Hydrogen bonds; hydroxypropyl-β-cyclodextrin; inclusion complex; Instrument industry; Investigations; Product development; Simulation methods; solubilization; Toxicity; β-cyclodextrin; United States; Massachusetts; China; inclusion complex; hydroxypropyl-β-cyclodextrin; Ethanamizuril; solubilization; β-cyclodextrin

Ethanamizuril (EZL) is a new anticoccidial drug developed by our Shanghai Veterinary Research Institute. Since EZL is almost insoluble in water, we conducted a study to improve the solubility of EZL by forming inclusion complexes with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD)....