MutaBind estimates and interprets the effects of sequence variants on protein–protein interactions

• Published in: Nucleic acids research Vol. 44; no. W1; pp. W494 - W501
• Main Authors: Li, Minghui, Simonetti, Franco L., Goncearenco, Alexander, Panchenko, Anna R.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 08.07.2016
• Subjects: Algorithms; Binding Sites; Datasets as Topic; Evolution, Molecular; Genetic Fitness; Humans; Internet; Molecular Dynamics Simulation; Neoplasms - genetics; Protein Binding - genetics; Protein Interaction Mapping - methods; Protein Interaction Maps - genetics; Proteins - chemistry; Proteins - genetics; Proteins - metabolism; Software; Web Server issue

Proteins engage in highly selective interactions with their macromolecular partners. Sequence variants that alter protein binding affinity may cause significant perturbations or complete abolishment of function, potentially leading to diseases. There exists a persistent need to develop a mechanistic...