HLA-binding properties of tumor neoepitopes in humans

• Published in: Cancer immunology research Vol. 2; no. 6; p. 522
• Main Authors: Fritsch, Edward F, Rajasagi, Mohini, Ott, Patrick A, Brusic, Vladimir, Hacohen, Nir, Wu, Catherine J
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Algorithms; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; Cancer Vaccines - immunology; Epitopes, T-Lymphocyte - genetics; Epitopes, T-Lymphocyte - metabolism; Histocompatibility Antigens Class I - metabolism; Humans; Immunity, Cellular - genetics; Immunity, Cellular - immunology; Mutation, Missense - genetics; Mutation, Missense - immunology; Neoplasms - genetics; Neoplasms - immunology; T-Lymphocytes - immunology

Cancer genome sequencing has enabled the rapid identification of the complete repertoire of coding sequence mutations within a patient's tumor and facilitated their use as personalized immunogens. Although a variety of techniques are available to assist in the selection of mutation-defined epit...