The neutralizing response to SARS-CoV-2 Omicron variants BA.1 and BA.2 in COVID-19 patients and homologous and heterologous vaccinees

• Published in: Human vaccines & immunotherapeutics Vol. 18; no. 6; p. 2129196
• Main Authors: Dapporto, Francesca, Leonardi, Margherita, Trombetta, Claudia Maria, Semplici, Claudia, Piu, Pietro, Piccini, Giulia, Benincasa, Linda, Marchi, Serena, Andreano, Emanuele, Lovreglio, Piero, Buonvino, Nicola, Decaro, Nicola, Stufano, Angela, Lorusso, Eleonora, Bombardieri, Emilio, Ruello, Antonella, Viviani, Simonetta, Rappuoli, Rino, Molesti, Eleonora, Manenti, Alessandro, Montomoli, Emanuele
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 30.11.2022; Taylor & Francis Group
• Subjects: Antibodies, Neutralizing; Antibodies, Viral; Brief Report; Coronavirus – Brief Report; COVID-19 - prevention & control; Humans; hybrid immunity; mrna booster; neutralizing antibodies; omicron ba.1; omicron ba.2; Patients; sars-cov-2; SARS-CoV-2 - genetics; sars-cov-2 vaccines; Hybrid immunity; Omicron BA.1; mRNA booster; SARS-CoV-2; Omicron BA.2; SARS-CoV-2 vaccines; neutralizing antibodies

The rapid replacement of Omicron BA.1 by BA.2 sublineage is very alarming, raising the question of whether BA.2 can escape the immunity acquired after BA.1 infection. We compared the neutralizing activity toward the Omicron BA.1 and BA.2 sub-lineages in five groups: COVID-19 patients; subjects who h...