Defining the Hallmarks of Metastasis

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 12; pp. 3011 - 3027
• Main Authors: Welch, Danny R., Hurst, Douglas R.
• Format: Journal Article
• Language: English
• Published: United States 15.06.2019
• Subjects: Animals; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Tumor Microenvironment

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as interactions between cancer cells and multiple microenvironments. The outcome is the development of a nearby or distant discontiguous seconda...