Combining Case-Control and Case-Trio Data From the Same Population in Genetic Association Analyses: Overview of Approaches and Illustration With a Candidate Gene Study

• Published in: American journal of epidemiology Vol. 170; no. 5; pp. 657 - 664
• Main Authors: Infante-Rivard, Claire, Mirea, Lucia, Bull, Shelley B.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.09.2009; Oxford Publishing Limited (England)
• Subjects: Analysis. Health state; association; Biological and medical sciences; Case studies; Case-Control Studies; Epidemiology; General aspects; genetic; Genetic disorders; Genetic Variation - genetics; Genome-Wide Association Study - methods; Genotype; Genotype & phenotype; Humans; Leukemia; linkage disequilibrium; Medical sciences; Miscellaneous; Models, Genetic; nuclear family; Offspring; polymorphism; Population genetics; Population structure; Public health. Hygiene; Public health. Hygiene-occupational medicine; Research methodology; Statistical methods; statistical models; nuclear family; statistical models; association; polymorphism, genetic; models, genetic; case-control studies; genotype; linkage disequilibrium; Human; genetic; models; Typing; Family study; Genotype; Review; Case control study; Epidemiology; Population genetics; Nuclear family; Association; Gene; Statistical model; Typology; Public health; Polymorphism

In genetic association studies, investigators compare allele or genotype frequencies in unrelated case and control subjects or examine preferential allele transmissions from parents to affected offspring. In many genetic case-control studies, the collection of DNA material extends to relatives such...