Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401

• Published in: Marine drugs Vol. 18; no. 11; p. 547
• Main Authors: Dai, Yu, Li, Kunlong, She, Jianglian, Zeng, Yanbo, Wang, Hao, Liao, Shengrong, Lin, Xiuping, Yang, Bin, Wang, Junfeng, Tao, Huaming, Dai, Haofu, Zhou, Xuefeng, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 30.10.2020; MDPI AG
• Subjects: A549 Cells; absolute configurations; acetylcholinesterase; Acetylcholinesterase - metabolism; AChE inhibitory; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Benzofurans - isolation & purification; Benzofurans - pharmacology; Cholinesterase Inhibitors - isolation & purification; Cholinesterase Inhibitors - pharmacology; circular dichroism spectroscopy; Cochliobolus lunatus; computer simulation; Curvularia - metabolism; Curvularia lunata; drugs; fungi; glycerol; Glyceryl Ethers - isolation & purification; Glyceryl Ethers - pharmacology; GPI-Linked Proteins - antagonists & inhibitors; GPI-Linked Proteins - metabolism; HeLa Cells; Humans; K562 Cells; lipopeptides; Lipopeptides - isolation & purification; Lipopeptides - pharmacology; Molecular Docking Simulation; Molecular Structure; phthalide; phthalides; Structure-Activity Relationship; AChE inhibitory; phthalide; lipopeptides; Cochliobolus lunatus; absolute configurations

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4–6). The structures of the new compounds, including t...