Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections

• Published in: Nephrology, dialysis, transplantation Vol. 22; no. 3; pp. 801 - 806
• Main Authors: Zoccali, Carmine, Maas, Renke, Cutrupi, Sebastiano, Pizzini, Patrizia, Finocchiaro, Piero, Cambareri, Francesco, Panuccio, Vincenzo, Martorano, Carmela, Schulze, Friedrich, Enia, Giuseppe, Tripepi, Giovanni, Boger, Rainer
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2007; Oxford Publishing Limited (England)
• Subjects: Acute Disease; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Arginine - analogs & derivatives; Arginine - blood; asymmetrical dimethyl-arginine; Bacterial Infections - blood; Bacterial Infections - physiopathology; Biological and medical sciences; Biomarkers - blood; Blood Pressure - physiology; C-reactive protein; C-Reactive Protein - metabolism; Calcitonin - blood; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Creatinine - blood; Disease Progression; Emergency and intensive care: renal failure. Dialysis management; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycoproteins; Human viral diseases; Humans; Infectious diseases; inflammation; Inflammation - blood; Intensive care medicine; interleukin-6; Interleukin-6 - blood; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - blood; procalcitonin; Protein Precursors - blood; Renal failure; Severity of Illness Index; Tyrosine - analogs & derivatives; Tyrosine - blood; Viral diseases; Viral hepatitis; procalcitonin; C-reactive protein; asymmetrical dimethyl-arginine; inflammation; interleukin-6; Kidney disease; Urinary system disease; Hemodialysis; Procalcitonin; Inflammation; Infection; Interleukin 6; Extrarenal dialysis; Arginine; Aminoacid; Renal failure; C reactive protein

Background and methods. The endogenous inhibitor of nitric oxide synthase (NOs) asymmetrical dimethyl-arginine (ADMA) has been implicated as a possible modulator of inducible NOs during acute inflammation. We examined the evolution in the plasma concentration of ADMA measured at the clinical outset...