Role of MHC Class II on Memory B Cells in Post-Germinal Center B Cell Homeostasis and Memory Response

• Published in: Journal of Immunology Vol. 176; no. 4; pp. 2122 - 2133
• Main Authors: Shimoda, Michiko, Li, Tao, Pihkala, Jeanene P. S, Koni, Pandelakis A
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.02.2006
• Subjects: Animals; Antigens - immunology; B-Lymphocytes - cytology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Cell Differentiation - immunology; Cell Proliferation; Germinal Center - cytology; Germinal Center - immunology; Histocompatibility Antigens Class II - immunology; Histocompatibility Antigens Class II - metabolism; Homeostasis; Immunologic Memory - immunology; Mice; Mice, Inbred C57BL; Phenotype; T-Lymphocytes - immunology

We investigated the role of B cell Ag presentation in homeostasis of the memory B cell compartment in a mouse model where a conditional allele for the beta-chain of MHC class II (MHC-II) is deleted in the vast majority of all B cells by cd19 promoter-mediated expression of Cre recombinase (IA-B mice...