Molecular Signatures of End-Stage Heart Failure

To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for m...

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Published in	Journal of cardiac failure Vol. 17; no. 10; pp. 867 - 874
Main Authors	Lin, David, Hollander, Zsuzsanna, Meredith, Anna, Stadnick, Ellamae, Sasaki, Mayu, Cohen Freue, Gabriela, Qasimi, Pooran, Mui, Alice, Ng, Raymond T., Balshaw, Robert, Wilson-McManus, Janet E., Wishart, David, Hau, David, Keown, Paul A., McMaster, Robert, McManus, Bruce M.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.10.2011
Subjects	Adult Aged Cardiomyopathies - blood Cardiomyopathies - genetics Cardiovascular Case-Control Studies Female Gene Expression Profiling genomics Heart failure Heart Failure - blood Heart Failure - genetics Humans Male metabolomics Middle Aged Proteomics Severity of Illness Index Heart failure genomics proteomics metabolomics
Online Access	Get full text
ISSN	1071-9164 1532-8414 1532-8414
DOI	10.1016/j.cardfail.2011.07.001

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Abstract	To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored. Microarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups. No genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure. Multiple “-omic” analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage.
AbstractList	To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored. Microarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups. No genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure. Multiple "-omic" analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage. To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored.BACKGROUNDTo date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored.Microarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups.METHODSMicroarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups.No genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure.RESULTSNo genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure.Multiple "-omic" analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage.CONCLUSIONMultiple "-omic" analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage. Abstract Background To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored. Methods Microarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups. Results No genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure. Conclusion Multiple “-omic” analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage.
Author	Wilson-McManus, Janet E. Balshaw, Robert Mui, Alice Wishart, David McMaster, Robert Sasaki, Mayu Hollander, Zsuzsanna Lin, David Keown, Paul A. Qasimi, Pooran Stadnick, Ellamae Ng, Raymond T. Hau, David McManus, Bruce M. Meredith, Anna Cohen Freue, Gabriela
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Cites_doi	10.1161/01.CIR.0000150539.72783.BF 10.2741/1977 10.1016/j.ejheart.2006.07.006 10.1016/S0735-1097(03)00043-3 10.1074/mcp.T600050-MCP200 10.1016/j.tox.2009.03.012 10.1371/journal.pone.0016957 10.1002/elps.1150191123 10.1161/01.CIR.102.25.3046 10.1111/j.1600-6143.2005.01119.x 10.1096/fj.05-4095fje 10.1016/j.healun.2009.04.025 10.1016/S0167-5273(00)00300-4 10.1016/0735-1097(96)00214-8 10.1016/j.jacc.2008.12.064 10.1152/physiolgenomics.00148.2002 10.1002/pmic.200300721 10.1074/mcp.M110.000554 10.1016/j.ejheart.2004.05.008 10.1093/nar/gkp356 10.1074/mcp.R500012-MCP200 10.1016/j.amjcard.2005.03.006 10.1161/01.CIR.0000148178.19465.11 10.1111/j.1365-2141.2004.04977.x 10.1016/S1053-2498(00)00173-X 10.1073/pnas.162370099 10.1016/j.jacc.2008.11.046 10.1371/journal.pone.0004871 10.1152/physiolgenomics.00022.2003 10.1038/nrg1470 10.1038/ncpcardio0710 10.1023/A:1025433721505 10.1056/NEJMra0800239 10.1161/01.CIR.100.9.999 10.1016/j.lab.2005.10.005 10.1515/CCLM.2005.084 10.1093/oxfordjournals.eurheartj.a015268 10.1016/j.jacc.2006.05.062 10.1136/hrt.2002.007005 10.1038/nature06802 10.1073/pnas.0436564100 10.1016/S0002-9343(98)00385-4 10.1042/BST0341313 10.1152/physiolgenomics.00255.2004 10.1097/TP.0b013e31817eef7b 10.1016/j.ejheart.2006.05.004 10.1111/j.1399-0012.2004.00197.x 10.1007/s11306-007-0063-5 10.1152/physiolgenomics.00299.2007
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References	Dunn, Broadhurst, Deepak, Buch, McDowell, Spasic (bib20) 2007; 3 Francis (bib33) 2001; 110 Chen, Park, Li, Missov, Hou, Han (bib12) 2003; 14 Fildes, Shaw, Yonan, Williams (bib35) 2009; 53 Beisvag, Lehre, Midelfart, Aass, Geiran, Sandvik (bib13) 2006; 8 Cugno, Mari, Meroni, Gronda, Vicari, Frigerio (bib42) 2004; 126 Liew, Dzau (bib2) 2004; 5 Lommi, Kupari, Koskinen, Naveri, Leinonen, Pulkki (bib32) 1996; 28 Damy, Kirsch, Khouzami, Caramelle, Le Corvoisier, Roudot-Thoraval (bib47) 2009; 4 Kittleson, Minhas, Irizarry, Ye, Edness, Breton (bib9) 2005; 21 Wishart (bib22) 2005; 5 Anker, von Haehling (bib36) 2004; 90 Braunwald (bib4) 2008; 358 Lin, Hollander, Ng, Imai, Ignaszewski, Balshaw (bib23) 2009; 28 Sato, Miyamoto, Taniguchi, Nishio, Kita, Fujiwara (bib41) 2006; 12 Narula, Haider, Arbustini, Chandrashekhar (bib45) 2006; 3 Devaux, Scholz, Hirche, Klovekorn, Schaper (bib43) 1997; 18 Donahue, Marchuk, Rockman (bib1) 2006; 48 Tschope, Walther, Escher, Spillmann, Du, Altmann (bib38) 2005; 19 Liew (bib16) 2005; 43 Kittleson, Ye, Irizarry, Minhas, Edness, Conte (bib14) 2004; 110 Kuner, Barth, Ruschhaupt, Buness, Zwermann, Kreuzer (bib17) 2008; 34 Margulies, Bednarik, Dries (bib29) 2009; 53 Horwitz, Tsai, Putt, Gilmore, Lepore, Parmacek (bib28) 2004; 110 Freue, Sasaki, Meredith, Gunther, Bergman, Takhar (bib24) 2010; 9 Anglicheau, Suthanthiran (bib27) 2008; 86 Schoels, Dengler, Richter, Meuer, Giese (bib30) 2004; 18 Corbett, Why, Wheeler, Richardson, Archard, Yacoub (bib19) 1998; 19 Lainscak, Doehner, Anker (bib5) 2007; 9 Baird (bib39) 2006; 34 Yang, Moravec, Sussman, DiPaola, Fu, Hawthorn (bib7) 2000; 102 Boheler, Volkova, Morrell, Garg, Zhu, Margulies (bib8) 2003; 100 Xia, Psychogios, Young, Wishart (bib26) 2009; 37 Mosnier, Griffin (bib44) 2006; 11 Costa, Silva, Tavares, Vitorino, Amado, Carvalho (bib46) 2009; 260 Psychogios, Hau, Peng, Guo, Mandal, Bouatra (bib25) 2011; 6 Davis, Gurbel, Gattis, Fuzaylov, Nair, O'Connor (bib40) 2000; 75 Liew, Ma, Tang, Zheng, Dempsey (bib15) 2006; 147 Dos Remedios, Liew, Allen, Winslow, Van Eyk, Dunn (bib21) 2003; 24 Torre-Amione (bib6) 2005; 95 Steenman, Lamirault, Le Meur, Le Cunff, Escande, Leger (bib10) 2005; 7 Blaxall, Tschannen-Moran, Milano, Koch (bib11) 2003; 41 Kubota, Miyagishima, Alvarez, Kormos, Rosenblum, Demetris (bib37) 2000; 19 Steenman, Chen, Le Cunff, Lamirault, Varro, Hoffman (bib3) 2003; 12 Gerszten, Wang (bib18) 2008; 451 Mann (bib31) 1999; 100 Tan, Moravec, Li, Apperson-Hansen, McCarthy, Young (bib34) 2002; 99 Boheler (10.1016/j.cardfail.2011.07.001_bib8) 2003; 100 Donahue (10.1016/j.cardfail.2011.07.001_bib1) 2006; 48 Chen (10.1016/j.cardfail.2011.07.001_bib12) 2003; 14 Kittleson (10.1016/j.cardfail.2011.07.001_bib14) 2004; 110 Mann (10.1016/j.cardfail.2011.07.001_bib31) 1999; 100 Torre-Amione (10.1016/j.cardfail.2011.07.001_bib6) 2005; 95 Fildes (10.1016/j.cardfail.2011.07.001_bib35) 2009; 53 Costa (10.1016/j.cardfail.2011.07.001_bib46) 2009; 260 Margulies (10.1016/j.cardfail.2011.07.001_bib29) 2009; 53 Mosnier (10.1016/j.cardfail.2011.07.001_bib44) 2006; 11 Devaux (10.1016/j.cardfail.2011.07.001_bib43) 1997; 18 Damy (10.1016/j.cardfail.2011.07.001_bib47) 2009; 4 Baird (10.1016/j.cardfail.2011.07.001_bib39) 2006; 34 Liew (10.1016/j.cardfail.2011.07.001_bib16) 2005; 43 Psychogios (10.1016/j.cardfail.2011.07.001_bib25) 2011; 6 Braunwald (10.1016/j.cardfail.2011.07.001_bib4) 2008; 358 Dunn (10.1016/j.cardfail.2011.07.001_bib20) 2007; 3 Tan (10.1016/j.cardfail.2011.07.001_bib34) 2002; 99 Liew (10.1016/j.cardfail.2011.07.001_bib15) 2006; 147 Wishart (10.1016/j.cardfail.2011.07.001_bib22) 2005; 5 Steenman (10.1016/j.cardfail.2011.07.001_bib3) 2003; 12 Francis (10.1016/j.cardfail.2011.07.001_bib33) 2001; 110 Kubota (10.1016/j.cardfail.2011.07.001_bib37) 2000; 19 Liew (10.1016/j.cardfail.2011.07.001_bib2) 2004; 5 Lainscak (10.1016/j.cardfail.2011.07.001_bib5) 2007; 9 Davis (10.1016/j.cardfail.2011.07.001_bib40) 2000; 75 Blaxall (10.1016/j.cardfail.2011.07.001_bib11) 2003; 41 Narula (10.1016/j.cardfail.2011.07.001_bib45) 2006; 3 Steenman (10.1016/j.cardfail.2011.07.001_bib10) 2005; 7 Dos Remedios (10.1016/j.cardfail.2011.07.001_bib21) 2003; 24 Kuner (10.1016/j.cardfail.2011.07.001_bib17) 2008; 34 Anglicheau (10.1016/j.cardfail.2011.07.001_bib27) 2008; 86 Schoels (10.1016/j.cardfail.2011.07.001_bib30) 2004; 18 Corbett (10.1016/j.cardfail.2011.07.001_bib19) 1998; 19 Anker (10.1016/j.cardfail.2011.07.001_bib36) 2004; 90 Xia (10.1016/j.cardfail.2011.07.001_bib26) 2009; 37 Beisvag (10.1016/j.cardfail.2011.07.001_bib13) 2006; 8 Tschope (10.1016/j.cardfail.2011.07.001_bib38) 2005; 19 Yang (10.1016/j.cardfail.2011.07.001_bib7) 2000; 102 Lin (10.1016/j.cardfail.2011.07.001_bib23) 2009; 28 Lommi (10.1016/j.cardfail.2011.07.001_bib32) 1996; 28 Nesvizhskii (10.1016/j.cardfail.2011.07.001_bib50) 2005; 4 Sato (10.1016/j.cardfail.2011.07.001_bib41) 2006; 12 Horwitz (10.1016/j.cardfail.2011.07.001_bib28) 2004; 110 Kittleson (10.1016/j.cardfail.2011.07.001_bib9) 2005; 21 Freue (10.1016/j.cardfail.2011.07.001_bib24) 2010; 9 Cugno (10.1016/j.cardfail.2011.07.001_bib42) 2004; 126 Shilov (10.1016/j.cardfail.2011.07.001_bib48) 2007; 6 Kersey (10.1016/j.cardfail.2011.07.001_bib49) 2004; 4 Gerszten (10.1016/j.cardfail.2011.07.001_bib18) 2008; 451
References_xml	– volume: 95 start-page: 3C year: 2005 end-page: 8C ident: bib6 article-title: Immune activation in chronic heart failure publication-title: Am J Cardiol – volume: 28 start-page: 665 year: 1996 end-page: 672 ident: bib32 article-title: Blood ketone bodies in congestive heart failure publication-title: J Am Coll Cardiol – volume: 3 start-page: 681 year: 2006 end-page: 688 ident: bib45 article-title: Mechanisms of disease: apoptosis in heart failure—seeing hope in death publication-title: Nat Clin Pract Cardiovasc Med – volume: 28 start-page: 927 year: 2009 end-page: 935 ident: bib23 article-title: Whole blood genomic biomarkers of acute cardiac allograft rejection publication-title: J Heart Lung Transplant – volume: 110 start-page: 37S year: 2001 end-page: 46S ident: bib33 article-title: Pathophysiology of chronic heart failure publication-title: Am J Med – volume: 86 start-page: 192 year: 2008 end-page: 199 ident: bib27 article-title: Noninvasive prediction of organ graft rejection and outcome using gene expression patterns publication-title: Transplantation – volume: 75 start-page: 15 year: 2000 end-page: 21 ident: bib40 article-title: Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge publication-title: Int J Cardiol – volume: 41 start-page: 1096 year: 2003 end-page: 1106 ident: bib11 article-title: Differential gene expression and genomic patient stratification following left ventricular assist device support publication-title: J Am Coll Cardiol – volume: 18 start-page: 513 year: 2004 end-page: 517 ident: bib30 article-title: Detection of cardiac allograft rejection by real-time PCR analysis of circulating mononuclear cells publication-title: Clin Transplant – volume: 18 start-page: 470 year: 1997 end-page: 479 ident: bib43 article-title: Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure publication-title: Eur Heart J – volume: 110 start-page: 3815 year: 2004 end-page: 3821 ident: bib28 article-title: Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression publication-title: Circulation – volume: 19 start-page: 819 year: 2000 end-page: 824 ident: bib37 article-title: Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure publication-title: J Heart Lung Transplant – volume: 11 start-page: 2381 year: 2006 end-page: 2399 ident: bib44 article-title: Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities publication-title: Front Biosci – volume: 102 start-page: 3046 year: 2000 end-page: 3052 ident: bib7 article-title: Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays publication-title: Circulation – volume: 53 start-page: 1752 year: 2009 end-page: 1759 ident: bib29 article-title: Genomics, transcriptional profiling, and heart failure publication-title: J Am Coll Cardiol – volume: 100 start-page: 2754 year: 2003 end-page: 2759 ident: bib8 article-title: Sex- and age-dependent human transcriptome variability: implications for chronic heart failure publication-title: Proc Natl Acad Sci U S A – volume: 19 start-page: 2031 year: 1998 end-page: 2042 ident: bib19 article-title: Cardiac protein abnormalities in dilated cardiomyopathy detected by two-dimensional polyacrylamide gel electrophoresis publication-title: Electrophoresis – volume: 5 start-page: 2814 year: 2005 end-page: 2820 ident: bib22 article-title: Metabolomics: the principles and potential applications to transplantation publication-title: Am J Transplant – volume: 100 start-page: 999 year: 1999 end-page: 1008 ident: bib31 article-title: Mechanisms and models in heart failure: A combinatorial approach publication-title: Circulation – volume: 8 start-page: 381 year: 2006 end-page: 389 ident: bib13 article-title: Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data publication-title: Eur J Heart Fail – volume: 21 start-page: 299 year: 2005 end-page: 307 ident: bib9 article-title: Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure publication-title: Physiol Genom – volume: 9 start-page: 1954 year: 2010 end-page: 1967 ident: bib24 article-title: Proteomic signatures in plasma during early acute renal allograft rejection publication-title: Mol Cell Proteomics – volume: 99 start-page: 11387 year: 2002 end-page: 11392 ident: bib34 article-title: The gene expression fingerprint of human heart failure publication-title: Proc Natl Acad Sci U S A – volume: 126 start-page: 85 year: 2004 end-page: 92 ident: bib42 article-title: Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation publication-title: Br J Haematol – volume: 43 start-page: 462 year: 2005 end-page: 469 ident: bib16 article-title: Expressed genome molecular signatures of heart failure publication-title: Clin Chem Lab Med – volume: 147 start-page: 126 year: 2006 end-page: 132 ident: bib15 article-title: The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool publication-title: J Lab Clin Med – volume: 7 start-page: 157 year: 2005 end-page: 165 ident: bib10 article-title: Distinct molecular portraits of human failing hearts identified by dedicated cDNA microarrays publication-title: Eur J Heart Fail – volume: 19 start-page: 2057 year: 2005 end-page: 2059 ident: bib38 article-title: Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy publication-title: FASEB J – volume: 48 start-page: 1289 year: 2006 end-page: 1298 ident: bib1 article-title: Redefining heart failure: the utility of genomics publication-title: J Am Coll Cardiol – volume: 110 start-page: 3444 year: 2004 end-page: 3451 ident: bib14 article-title: Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy publication-title: Circulation – volume: 14 start-page: 251 year: 2003 end-page: 260 ident: bib12 article-title: Alterations of gene expression in failing myocardium following left ventricular assist device support publication-title: Physiol Genom – volume: 451 start-page: 949 year: 2008 end-page: 952 ident: bib18 article-title: The search for new cardiovascular biomarkers publication-title: Nature – volume: 6 start-page: e16957 year: 2011 ident: bib25 article-title: The human serum metabolome publication-title: PLoS ONE – volume: 260 start-page: 84 year: 2009 end-page: 96 ident: bib46 article-title: Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes publication-title: Toxicology – volume: 4 start-page: e4871 year: 2009 ident: bib47 article-title: Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities publication-title: PLoS ONE – volume: 3 start-page: 413 year: 2007 end-page: 426 ident: bib20 article-title: Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate publication-title: Metabolomics – volume: 90 start-page: 464 year: 2004 end-page: 470 ident: bib36 article-title: Inflammatory mediators in chronic heart failure: an overview publication-title: Heart – volume: 5 start-page: 811 year: 2004 end-page: 825 ident: bib2 article-title: Molecular genetics and genomics of heart failure publication-title: Nat Rev Genet – volume: 34 start-page: 88 year: 2008 end-page: 94 ident: bib17 article-title: Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies publication-title: Physiol Genom – volume: 53 start-page: 1013 year: 2009 end-page: 1020 ident: bib35 article-title: The immune system and chronic heart failure: is the heart in control? publication-title: J Am Coll Cardiol – volume: 34 start-page: 1313 year: 2006 end-page: 1317 ident: bib39 article-title: Blood genomic profiling: novel diagnostic and therapeutic strategies for stroke? publication-title: Biochem Soc Trans – volume: 37 start-page: W652 year: 2009 end-page: W660 ident: bib26 article-title: MetaboAnalyst: a web server for metabolomic data analysis and interpretation publication-title: Nucleic Acids Res – volume: 24 start-page: 251 year: 2003 end-page: 260 ident: bib21 article-title: Genomics, proteomics and bioinformatics of human heart failure publication-title: J Muscle Res Cell Motil – volume: 12 start-page: 97 year: 2003 end-page: 112 ident: bib3 article-title: Transcriptional analysis of failing and nonfailing human hearts publication-title: Physiol Genom – volume: 12 start-page: RA252 year: 2006 end-page: RA264 ident: bib41 article-title: Current understanding of biochemical markers in heart failure publication-title: Med Sci Monit – volume: 358 start-page: 2148 year: 2008 end-page: 2159 ident: bib4 article-title: Biomarkers in heart failure publication-title: N Engl J Med – volume: 9 start-page: 2 year: 2007 end-page: 3 ident: bib5 article-title: Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?! publication-title: Eur J Heart Fail – volume: 110 start-page: 3815 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib28 article-title: Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression publication-title: Circulation doi: 10.1161/01.CIR.0000150539.72783.BF – volume: 11 start-page: 2381 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib44 article-title: Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities publication-title: Front Biosci doi: 10.2741/1977 – volume: 9 start-page: 2 year: 2007 ident: 10.1016/j.cardfail.2011.07.001_bib5 article-title: Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?! publication-title: Eur J Heart Fail doi: 10.1016/j.ejheart.2006.07.006 – volume: 41 start-page: 1096 year: 2003 ident: 10.1016/j.cardfail.2011.07.001_bib11 article-title: Differential gene expression and genomic patient stratification following left ventricular assist device support publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(03)00043-3 – volume: 6 start-page: 1638 year: 2007 ident: 10.1016/j.cardfail.2011.07.001_bib48 article-title: The Paragon algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra publication-title: Mol Cell Proteomics doi: 10.1074/mcp.T600050-MCP200 – volume: 260 start-page: 84 year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib46 article-title: Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes publication-title: Toxicology doi: 10.1016/j.tox.2009.03.012 – volume: 6 start-page: e16957 year: 2011 ident: 10.1016/j.cardfail.2011.07.001_bib25 article-title: The human serum metabolome publication-title: PLoS ONE doi: 10.1371/journal.pone.0016957 – volume: 19 start-page: 2031 year: 1998 ident: 10.1016/j.cardfail.2011.07.001_bib19 article-title: Cardiac protein abnormalities in dilated cardiomyopathy detected by two-dimensional polyacrylamide gel electrophoresis publication-title: Electrophoresis doi: 10.1002/elps.1150191123 – volume: 102 start-page: 3046 year: 2000 ident: 10.1016/j.cardfail.2011.07.001_bib7 article-title: Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays publication-title: Circulation doi: 10.1161/01.CIR.102.25.3046 – volume: 5 start-page: 2814 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib22 article-title: Metabolomics: the principles and potential applications to transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2005.01119.x – volume: 19 start-page: 2057 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib38 article-title: Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy publication-title: FASEB J doi: 10.1096/fj.05-4095fje – volume: 28 start-page: 927 year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib23 article-title: Whole blood genomic biomarkers of acute cardiac allograft rejection publication-title: J Heart Lung Transplant doi: 10.1016/j.healun.2009.04.025 – volume: 75 start-page: 15 year: 2000 ident: 10.1016/j.cardfail.2011.07.001_bib40 article-title: Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge publication-title: Int J Cardiol doi: 10.1016/S0167-5273(00)00300-4 – volume: 28 start-page: 665 year: 1996 ident: 10.1016/j.cardfail.2011.07.001_bib32 article-title: Blood ketone bodies in congestive heart failure publication-title: J Am Coll Cardiol doi: 10.1016/0735-1097(96)00214-8 – volume: 53 start-page: 1752 year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib29 article-title: Genomics, transcriptional profiling, and heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.12.064 – volume: 12 start-page: 97 year: 2003 ident: 10.1016/j.cardfail.2011.07.001_bib3 article-title: Transcriptional analysis of failing and nonfailing human hearts publication-title: Physiol Genom doi: 10.1152/physiolgenomics.00148.2002 – volume: 4 start-page: 1985 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib49 article-title: The International Protein Index: an integrated database for proteomics experiments publication-title: Proteomics doi: 10.1002/pmic.200300721 – volume: 9 start-page: 1954 year: 2010 ident: 10.1016/j.cardfail.2011.07.001_bib24 article-title: Proteomic signatures in plasma during early acute renal allograft rejection publication-title: Mol Cell Proteomics doi: 10.1074/mcp.M110.000554 – volume: 7 start-page: 157 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib10 article-title: Distinct molecular portraits of human failing hearts identified by dedicated cDNA microarrays publication-title: Eur J Heart Fail doi: 10.1016/j.ejheart.2004.05.008 – volume: 37 start-page: W652 issue: Web Server issue year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib26 article-title: MetaboAnalyst: a web server for metabolomic data analysis and interpretation publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp356 – volume: 4 start-page: 1419 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib50 article-title: Interpretation of shotgun proteomic data: the protein inference problem publication-title: Mol Cell Proteomics doi: 10.1074/mcp.R500012-MCP200 – volume: 95 start-page: 3C year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib6 article-title: Immune activation in chronic heart failure publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2005.03.006 – volume: 110 start-page: 3444 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib14 article-title: Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy publication-title: Circulation doi: 10.1161/01.CIR.0000148178.19465.11 – volume: 126 start-page: 85 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib42 article-title: Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2004.04977.x – volume: 19 start-page: 819 year: 2000 ident: 10.1016/j.cardfail.2011.07.001_bib37 article-title: Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure publication-title: J Heart Lung Transplant doi: 10.1016/S1053-2498(00)00173-X – volume: 99 start-page: 11387 year: 2002 ident: 10.1016/j.cardfail.2011.07.001_bib34 article-title: The gene expression fingerprint of human heart failure publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.162370099 – volume: 53 start-page: 1013 year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib35 article-title: The immune system and chronic heart failure: is the heart in control? publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.11.046 – volume: 4 start-page: e4871 year: 2009 ident: 10.1016/j.cardfail.2011.07.001_bib47 article-title: Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities publication-title: PLoS ONE doi: 10.1371/journal.pone.0004871 – volume: 14 start-page: 251 year: 2003 ident: 10.1016/j.cardfail.2011.07.001_bib12 article-title: Alterations of gene expression in failing myocardium following left ventricular assist device support publication-title: Physiol Genom doi: 10.1152/physiolgenomics.00022.2003 – volume: 5 start-page: 811 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib2 article-title: Molecular genetics and genomics of heart failure publication-title: Nat Rev Genet doi: 10.1038/nrg1470 – volume: 12 start-page: RA252 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib41 article-title: Current understanding of biochemical markers in heart failure publication-title: Med Sci Monit – volume: 3 start-page: 681 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib45 article-title: Mechanisms of disease: apoptosis in heart failure—seeing hope in death publication-title: Nat Clin Pract Cardiovasc Med doi: 10.1038/ncpcardio0710 – volume: 24 start-page: 251 year: 2003 ident: 10.1016/j.cardfail.2011.07.001_bib21 article-title: Genomics, proteomics and bioinformatics of human heart failure publication-title: J Muscle Res Cell Motil doi: 10.1023/A:1025433721505 – volume: 358 start-page: 2148 year: 2008 ident: 10.1016/j.cardfail.2011.07.001_bib4 article-title: Biomarkers in heart failure publication-title: N Engl J Med doi: 10.1056/NEJMra0800239 – volume: 100 start-page: 999 year: 1999 ident: 10.1016/j.cardfail.2011.07.001_bib31 article-title: Mechanisms and models in heart failure: A combinatorial approach publication-title: Circulation doi: 10.1161/01.CIR.100.9.999 – volume: 147 start-page: 126 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib15 article-title: The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool publication-title: J Lab Clin Med doi: 10.1016/j.lab.2005.10.005 – volume: 43 start-page: 462 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib16 article-title: Expressed genome molecular signatures of heart failure publication-title: Clin Chem Lab Med doi: 10.1515/CCLM.2005.084 – volume: 18 start-page: 470 year: 1997 ident: 10.1016/j.cardfail.2011.07.001_bib43 article-title: Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure publication-title: Eur Heart J doi: 10.1093/oxfordjournals.eurheartj.a015268 – volume: 48 start-page: 1289 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib1 article-title: Redefining heart failure: the utility of genomics publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2006.05.062 – volume: 90 start-page: 464 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib36 article-title: Inflammatory mediators in chronic heart failure: an overview publication-title: Heart doi: 10.1136/hrt.2002.007005 – volume: 451 start-page: 949 year: 2008 ident: 10.1016/j.cardfail.2011.07.001_bib18 article-title: The search for new cardiovascular biomarkers publication-title: Nature doi: 10.1038/nature06802 – volume: 100 start-page: 2754 year: 2003 ident: 10.1016/j.cardfail.2011.07.001_bib8 article-title: Sex- and age-dependent human transcriptome variability: implications for chronic heart failure publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0436564100 – volume: 110 start-page: 37S issue: Suppl 7A year: 2001 ident: 10.1016/j.cardfail.2011.07.001_bib33 article-title: Pathophysiology of chronic heart failure publication-title: Am J Med doi: 10.1016/S0002-9343(98)00385-4 – volume: 34 start-page: 1313 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib39 article-title: Blood genomic profiling: novel diagnostic and therapeutic strategies for stroke? publication-title: Biochem Soc Trans doi: 10.1042/BST0341313 – volume: 21 start-page: 299 year: 2005 ident: 10.1016/j.cardfail.2011.07.001_bib9 article-title: Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure publication-title: Physiol Genom doi: 10.1152/physiolgenomics.00255.2004 – volume: 86 start-page: 192 year: 2008 ident: 10.1016/j.cardfail.2011.07.001_bib27 article-title: Noninvasive prediction of organ graft rejection and outcome using gene expression patterns publication-title: Transplantation doi: 10.1097/TP.0b013e31817eef7b – volume: 8 start-page: 381 year: 2006 ident: 10.1016/j.cardfail.2011.07.001_bib13 article-title: Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data publication-title: Eur J Heart Fail doi: 10.1016/j.ejheart.2006.05.004 – volume: 18 start-page: 513 year: 2004 ident: 10.1016/j.cardfail.2011.07.001_bib30 article-title: Detection of cardiac allograft rejection by real-time PCR analysis of circulating mononuclear cells publication-title: Clin Transplant doi: 10.1111/j.1399-0012.2004.00197.x – volume: 3 start-page: 413 year: 2007 ident: 10.1016/j.cardfail.2011.07.001_bib20 article-title: Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate publication-title: Metabolomics doi: 10.1007/s11306-007-0063-5 – volume: 34 start-page: 88 year: 2008 ident: 10.1016/j.cardfail.2011.07.001_bib17 article-title: Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies publication-title: Physiol Genom doi: 10.1152/physiolgenomics.00299.2007
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Snippet	To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility... Abstract Background To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The...
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SubjectTerms	Adult Aged Cardiomyopathies - blood Cardiomyopathies - genetics Cardiovascular Case-Control Studies Female Gene Expression Profiling genomics Heart failure Heart Failure - blood Heart Failure - genetics Humans Male metabolomics Middle Aged Proteomics Severity of Illness Index
Title	Molecular Signatures of End-Stage Heart Failure
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