Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution

• Published in: The Journal of immunology (1950) Vol. 180; no. 5; pp. 3512 - 3519
• Main Authors: Hong, Song, Porter, Timothy F, Lu, Yan, Oh, Sungwhan F, Pillai, Padmini S, Serhan, Charles N
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.03.2008
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Ascitic Fluid - immunology; Ascitic Fluid - metabolism; Ascitic Fluid - pathology; Eicosapentaenoic Acid - analogs & derivatives; Eicosapentaenoic Acid - antagonists & inhibitors; Eicosapentaenoic Acid - blood; Eicosapentaenoic Acid - metabolism; Eicosapentaenoic Acid - physiology; Humans; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Inflammation Mediators - physiology; Macrophages, Peritoneal - metabolism; Macrophages, Peritoneal - pathology; Male; Mice; Mice, Inbred Strains; Neutrophils - metabolism; Neutrophils - pathology; Phagocytosis - immunology; Signal Transduction - immunology

Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is a potent anti-inflammatory and proresolving mediator derived from the omega-3 eicosapentaenoic acid. In this study, we report the RvE1 metabolome, namely, the metabolic products derived from RvE1. RvE1 was converted...