Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl − transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro . The best transporters proved effective against the methicillin-resis...

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Published inChemical communications (Cambridge, England) Vol. 52; no. 48; pp. 7560 - 7563
Main Authors Share, Andrew I., Patel, Khushali, Nativi, Cristina, Cho, Eun J., Francesconi, Oscar, Busschaert, Nathalie, Gale, Philip A., Roelens, Stefano, Sessler, Jonathan L.
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Anion Transport Proteins - metabolism
Anions
Anti-Bacterial Agents - metabolism
antibiotic resistance
chemical reactions
Chlorides
Chlorides - metabolism
In vitro testing
Liposomes
Membranes
methicillin
methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - growth & development
Methicillin-Resistant Staphylococcus aureus - metabolism
Microbial Sensitivity Tests
Molecular Structure
MRSA
Receptors
Staphylococcus
Staphylococcus aureus
transporters
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ISSN1359-7345
1364-548X
1364-548X
DOI10.1039/C6CC03645G

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Summary:A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl − transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro . The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro .
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Present address: Silver Center for Arts and Science, New York University, Department of Chemistry, 100 Washington Square E, New York, NY 10003, USA.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C6CC03645G