Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 10; pp. 2684 - 2696
• Main Authors: Poźniak, Joanna, Nsengimana, Jérémie, Laye, Jonathan P., O’Shea, Sally J., Diaz, Joey Mark S., Droop, Alastair P., Filia, Anastasia, Harland, Mark, Davies, John R., Mell, Tracey, Randerson-Moor, Juliette A., Muralidhar, Sathya, Hogan, Sabrina A., Freiberger, Sandra Nicole, Levesque, Mitchell P., Cook, Graham P., Bishop, D. Timothy, Newton-Bishop, Julia
• Format: Journal Article
• Language: English
• Published: United States 15.05.2019
• Subjects: Down-Regulation; Humans; Immunotherapy; Melanoma - genetics; Signal Transduction - genetics; Skin Neoplasms - genetics

The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous melanoma cohort. Bioinformatic analysis of 703 tumor transcrip...