Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm

• Published in: Cell transplantation Vol. 33; p. 9636897231221882
• Main Authors: Chen, Cheng-Fong, Chen, Yi-Chung, Fu, Yu-Show, Tsai, Shang-Wen, Wu, Po-Kuei, Chen, Chao-Ming, Chen, Wei-Ming, Wu, Hung-Ta Hondar, Lee, Chia-Hsin, Chang, Chao-Liang, Lin, Po-Cheng, Kao, Yong-Cheng, Chen, Chun-Hung, Chuang, Ming-Hsi
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2024; Sage Publications Ltd; SAGE Publishing
• Subjects: Adverse events; Humans; Injections, Intra-Articular; Knee; Mesenchymal Stem Cells; Osteoarthritis; Osteoarthritis, Knee - therapy; Pain; Pilot Projects; Stem cells; Visual perception; GXCPC1; knee osteoarthritis; allogeneic adipose-derived mesenchymal stem cells (ADSCs); safety; tolerability

The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts:...