Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

• Published in: Pharmaceutics Vol. 12; no. 2; p. 144
• Main Authors: Xi, Ziyue, Zhang, Wei, Fei, Yali, Cui, Mingshu, Xie, Luyao, Chen, Lu, Xu, Lu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 10.02.2020; MDPI AG
• Subjects: bioavailability; indomethacin; mesoporous silica nanoparticles; solid dispersion; solubility; mesoporous silica nanoparticles; solubility; bioavailability; solid dispersion; indomethacin

This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)—combined wit...