Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis

• Published in: Chemical science (Cambridge) Vol. 5; no. 10; pp. 3845 - 3852
• Main Authors: Ye, Deju, Shuhendler, Adam J., Pandit, Prachi, Brewer, Kimberly D., Tee, Sui Seng, Cui, Lina, Tikhomirov, Grigory, Rutt, Brian, Rao, Jianghong
• Format: Journal Article
• Language: English
• Published: England 01.01.2014
• Subjects: Apoptosis; Biocompatibility; Biomedical materials; Imaging; Magnetic resonance imaging; Self assembly; Surgical implants; Tumors

Non-invasive detection of caspase-3/7 activity in vivo has provided invaluable predictive information regarding tumor therapeutic efficacy and anti-tumor drug selection. Although a number of caspase-3/7 targeted fluorescence and positron emission tomography (PET) imaging probes have been developed,...