Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

• Published in: The Journal of immunology (1950) Vol. 180; no. 6; pp. 3655 - 3659
• Main Authors: Benson, Micah J, Dillon, Stacey R, Castigli, Emanuela, Geha, Raif S, Xu, Shengli, Lam, Kong-Peng, Noelle, Randolph J
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.03.2008
• Subjects: Animals; Antibody Formation - genetics; B-Cell Activating Factor - metabolism; B-Cell Activating Factor - physiology; B-Cell Activation Factor Receptor - biosynthesis; B-Cell Activation Factor Receptor - genetics; B-Cell Activation Factor Receptor - metabolism; B-Cell Maturation Antigen - biosynthesis; B-Cell Maturation Antigen - genetics; B-Cell Maturation Antigen - metabolism; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Bone Marrow Cells - metabolism; Cell Survival - genetics; Cell Survival - immunology; Immunologic Memory - genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Plasma Cells - cytology; Plasma Cells - immunology; Plasma Cells - metabolism; Transmembrane Activator and CAML Interactor Protein - biosynthesis; Transmembrane Activator and CAML Interactor Protein - genetics; Tumor Necrosis Factor Ligand Superfamily Member 13 - deficiency; Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics; Tumor Necrosis Factor Ligand Superfamily Member 13 - physiology

Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow rema...