Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL
Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow rema...
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Published in | The Journal of immunology (1950) Vol. 180; no. 6; pp. 3655 - 3659 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Am Assoc Immnol
15.03.2008
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Subjects | |
Online Access | Get full text |
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Abstract | Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived B(MEM) cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand). Thus, B(MEM) cells represent the only mature B2 lineage subset whose survival is independent of these ligands. We have previously shown that the TNFR family member receptor BCMA (B cell maturation Ag) is a critical survival receptor for BM-PC survival in vivo. We identify in this study the ligands critical for BM-PC survival and show that either BAFF or APRIL supports the survival of BM-PCs in vivo. These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity. |
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AbstractList | Memory B (B sub(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B sub(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived B sub(MEM) cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand). Thus, B sub(MEM) cells represent the only mature B2 lineage subset whose survival is independent of these ligands. We have previously shown that the TNFR family member receptor BCMA (B cell maturation Ag) is a critical survival receptor for BM-PC survival in vivo. We identify in this study the ligands critical for BM-PC survival and show that either BAFF or APRIL supports the survival of BM-PCs in vivo. These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity. Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived B(MEM) cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand). Thus, B(MEM) cells represent the only mature B2 lineage subset whose survival is independent of these ligands. We have previously shown that the TNFR family member receptor BCMA (B cell maturation Ag) is a critical survival receptor for BM-PC survival in vivo. We identify in this study the ligands critical for BM-PC survival and show that either BAFF or APRIL supports the survival of BM-PCs in vivo. These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity. Memory B (BMEM) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting BMEM cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived BMEM cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand). Thus, BMEM cells represent the only mature B2 lineage subset whose survival is independent of these ligands. We have previously shown that the TNFR family member receptor BCMA (B cell maturation Ag) is a critical survival receptor for BM-PC survival in vivo. We identify in this study the ligands critical for BM-PC survival and show that either BAFF or APRIL supports the survival of BM-PCs in vivo. These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity. |
Author | Xu, Shengli Noelle, Randolph J Castigli, Emanuela Benson, Micah J Dillon, Stacey R Geha, Raif S Lam, Kong-Peng |
Author_xml | – sequence: 1 fullname: Benson, Micah J – sequence: 2 fullname: Dillon, Stacey R – sequence: 3 fullname: Castigli, Emanuela – sequence: 4 fullname: Geha, Raif S – sequence: 5 fullname: Xu, Shengli – sequence: 6 fullname: Lam, Kong-Peng – sequence: 7 fullname: Noelle, Randolph J |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18322170$$D View this record in MEDLINE/PubMed |
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Snippet | Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity.... Memory B (BMEM) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity.... Memory B (B sub(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity.... |
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SubjectTerms | Animals Antibody Formation - genetics B-Cell Activating Factor - metabolism B-Cell Activating Factor - physiology B-Cell Activation Factor Receptor - biosynthesis B-Cell Activation Factor Receptor - genetics B-Cell Activation Factor Receptor - metabolism B-Cell Maturation Antigen - biosynthesis B-Cell Maturation Antigen - genetics B-Cell Maturation Antigen - metabolism B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cell Survival - genetics Cell Survival - immunology Immunologic Memory - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Plasma Cells - cytology Plasma Cells - immunology Plasma Cells - metabolism Transmembrane Activator and CAML Interactor Protein - biosynthesis Transmembrane Activator and CAML Interactor Protein - genetics Tumor Necrosis Factor Ligand Superfamily Member 13 - deficiency Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics Tumor Necrosis Factor Ligand Superfamily Member 13 - physiology |
Title | Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL |
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