Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression

• Published in: Journal of molecular and cellular cardiology Vol. 135; pp. 10 - 21
• Main Authors: Chen, Beidong, Zhao, Yang, Han, Duanyang, Zhao, Ban, Mao, Yonghui, Cui, Zhong-Kai, Chu, Yun-Chin, Feng, Lu, Yin, Sen, Wang, Cun-Yu, Wang, Xian, Xu, Ming-Jiang, Zhao, Gexin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2019
• Subjects: ANKH; Chronic kidney disease; Vascular calcification; Vascular smooth muscle cells; Wnt1; Vascular calcification; Chronic kidney disease; ANKH; Wnt1; Vascular smooth muscle cells

Wnt signaling plays a critical role in vascular calcification (VC). Wnt factors induce different physiological and pathological effects on cardiovascular functions. Wnt1, a ligand of Wnt/β-catenin signaling, promotes pro-angiogenesis and reduces myocardial infarction. The role of Wnt1 on VC in chron...