The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a...
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| Published in | Nucleic acids research Vol. 43; no. Database issue; pp. D726 - D736 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
28.01.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse-human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human-Mouse: Disease Connection, allows users to explore gene-phenotype-disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community. |
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| AbstractList | The Mouse Genome Database (MGD,
http://www.informatics.jax.org
) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community. The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse-human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human-Mouse: Disease Connection, allows users to explore gene-phenotype-disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community. |
| Author | Blake, Judith A Bult, Carol J Richardson, Joel E Eppig, Janan T Kadin, James A |
| Author_xml | – sequence: 1 givenname: Janan T surname: Eppig fullname: Eppig, Janan T email: janan.eppig@jax.org organization: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA janan.eppig@jax.org – sequence: 2 givenname: Judith A surname: Blake fullname: Blake, Judith A organization: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA – sequence: 3 givenname: Carol J surname: Bult fullname: Bult, Carol J organization: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA – sequence: 4 givenname: James A surname: Kadin fullname: Kadin, James A organization: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA – sequence: 5 givenname: Joel E surname: Richardson fullname: Richardson, Joel E organization: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25348401$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. 2015 |
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| Title | The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease |
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