Paternal age at birth is an important determinant of offspring telomere length

• Published in: Human molecular genetics Vol. 16; no. 24; pp. 3097 - 3102
• Main Authors: De Meyer, Tim, Rietzschel, Ernst R., De Buyzere, Marc L., De Bacquer, Dirk, Van Criekinge, Wim, De Backer, Guy G., Gillebert, Thierry C., Van Oostveldt, Patrick, Bekaert, Sofie
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.12.2007; Oxford Publishing Limited (England)
• Subjects: Adult; Age Factors; Aging - genetics; Biological and medical sciences; Cross-Sectional Studies; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Humans; Infant, Newborn; Longitudinal Studies; Male; Maternal Age; Middle Aged; Molecular and cellular biology; Paternal Age; Telomere - ultrastructure; Genetics; Birth; Paternal age; Telomere

Although evidence supports the function of telomere length (TL) as a marker for biological aging, no major determinants of TL are known besides inheritance, age and gender. Here we validate and, more importantly, assess the impact of paternal age at birth as a determinant for the offspring’s periphe...