In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects - Faideau, Mathilde; Kim, Jinho; Cormier, Kerry; Gilmore, Richard; Welch, Mackenzie; Auregan, Gwennaelle; Dufour, Noelle; Guillermier, Martine; Brouillet, Emmanuel; Hantraye, Philippe; Déglon, Nicole; Ferrante, Robert J.; et al. (Human molecular genetics, 2010)
Keywords: Aged; Amino Acid Transport System X-AG - metabolism; Animals; Astrocytes - metabolism; Astrocytes - pathology; Biological and medical sciences; Biological Transport; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism; Down-Regulation; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Glial Fibrillary Acidic Protein - metabolism; Glutamic Acid - metabolism; Humans; Huntington Disease - metabolism; Huntington Disease - pathology; Lentivirus - genetics; Medical sciences; Mice; Middle Aged; Molecular and cellular biology; Mutant Proteins - metabolism; Neostriatum - metabolism; Neostriatum - pathology; Neurology; Neurons - metabolism; Neurons - pathology; Peptides - metabolism; Phenotype; Receptors, N-Methyl-D-Aspartate - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; Time Factors; Trinucleotide Repeat Expansion - genetics; Nervous system diseases; Correlation; Huntingtin; Neuroglia; Rodentia; Huntington disease; Central nervous system; Astrocyte; Glutamate; Genetic disease; Cerebral disorder; In vivo; Vertebrata; Mammalia; Mouse; Central nervous system disease; Excitatory aminoacid; Neurotransmitter; Genetics; Degenerative disease; Extrapyramidal syndrome