Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas
Summary Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent...
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| Published in | Human pathology Vol. 41; no. 5; pp. 724 - 736 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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01.05.2010
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| Abstract | Summary Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM), adenomas, intestinal metaplasia (IM), or gastritis. Gastric carcinoma tissue and cell lines were studied for Bag-1 expression by Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR). The results demonstrated that Bag-1 proteins were differentially expressed in the nucleus or cytosol of MKN28, AGS, MKN45, KATO-III, or HGC-27 cell lines, despite similar levels of messenger RNA (mRNA) expression. The Bag-1 mRNA overexpression was detectable in 73.3% of 15 gastric carcinomas without significant difference in its encoding products' levels. The nuclear Bag-1 expression gradually decreased from gastritis, IM, adenoma to carcinoma ( P < .05), and negatively correlated with lymphatic invasion or lymph node metastasis, cytoplasmic Bag-1 expression, negative parafibromin expression, and poor prognosis ( P < .05). Cytoplasmic Bag-1 was weakly immunoreactive in carcinomas, compared with gastritis ( P < .05), and positively associated with invasive depth and poor prognosis of the carcinoma ( P < .05). The positive rate of Bag-1 mRNA expression was higher in adjacent IMs than carcinomas or adjacent NNM ( P < .05). Bag-1 mRNA was expressed more in carcinomas from female patients than the male counterparts ( P < .05). There was a positive correlation of Bag-1 mRNA expression with invasive depth and venous invasion ( P < .05). Our study indicated that aberrant expression and subcellular distribution of Bag-1 might play an important role in the malignant transformation of gastric epithelial cells and should be considered as a biomarker for gastric carcinogenesis, subsequent progression, and prognosis. |
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| AbstractList | Summary Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM), adenomas, intestinal metaplasia (IM), or gastritis. Gastric carcinoma tissue and cell lines were studied for Bag-1 expression by Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR). The results demonstrated that Bag-1 proteins were differentially expressed in the nucleus or cytosol of MKN28, AGS, MKN45, KATO-III, or HGC-27 cell lines, despite similar levels of messenger RNA (mRNA) expression. The Bag-1 mRNA overexpression was detectable in 73.3% of 15 gastric carcinomas without significant difference in its encoding products' levels. The nuclear Bag-1 expression gradually decreased from gastritis, IM, adenoma to carcinoma ( P < .05), and negatively correlated with lymphatic invasion or lymph node metastasis, cytoplasmic Bag-1 expression, negative parafibromin expression, and poor prognosis ( P < .05). Cytoplasmic Bag-1 was weakly immunoreactive in carcinomas, compared with gastritis ( P < .05), and positively associated with invasive depth and poor prognosis of the carcinoma ( P < .05). The positive rate of Bag-1 mRNA expression was higher in adjacent IMs than carcinomas or adjacent NNM ( P < .05). Bag-1 mRNA was expressed more in carcinomas from female patients than the male counterparts ( P < .05). There was a positive correlation of Bag-1 mRNA expression with invasive depth and venous invasion ( P < .05). Our study indicated that aberrant expression and subcellular distribution of Bag-1 might play an important role in the malignant transformation of gastric epithelial cells and should be considered as a biomarker for gastric carcinogenesis, subsequent progression, and prognosis. Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM), adenomas, intestinal metaplasia (IM), or gastritis. Gastric carcinoma tissue and cell lines were studied for Bag-1 expression by Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR). The results demonstrated that Bag-1 proteins were differentially expressed in the nucleus or cytosol of MKN28, AGS, MKN45, KATO-III, or HGC-27 cell lines, despite similar levels of messenger RNA (mRNA) expression. The Bag-1 mRNA overexpression was detectable in 73.3% of 15 gastric carcinomas without significant difference in its encoding products' levels. The nuclear Bag-1 expression gradually decreased from gastritis, IM, adenoma to carcinoma ( P < .05), and negatively correlated with lymphatic invasion or lymph node metastasis, cytoplasmic Bag-1 expression, negative parafibromin expression, and poor prognosis ( P < .05). Cytoplasmic Bag-1 was weakly immunoreactive in carcinomas, compared with gastritis ( P < .05), and positively associated with invasive depth and poor prognosis of the carcinoma ( P < .05). The positive rate of Bag-1 mRNA expression was higher in adjacent IMs than carcinomas or adjacent NNM ( P < .05). Bag-1 mRNA was expressed more in carcinomas from female patients than the male counterparts ( P < .05). There was a positive correlation of Bag-1 mRNA expression with invasive depth and venous invasion ( P < .05). Our study indicated that aberrant expression and subcellular distribution of Bag-1 might play an important role in the malignant transformation of gastric epithelial cells and should be considered as a biomarker for gastric carcinogenesis, subsequent progression, and prognosis. Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM), adenomas, intestinal metaplasia (IM), or gastritis. Gastric carcinoma tissue and cell lines were studied for Bag-1 expression by Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR). The results demonstrated that Bag-1 proteins were differentially expressed in the nucleus or cytosol of MKN28, AGS, MKN45, KATO-III, or HGC-27 cell lines, despite similar levels of messenger RNA (mRNA) expression. The Bag-1 mRNA overexpression was detectable in 73.3% of 15 gastric carcinomas without significant difference in its encoding products' levels. The nuclear Bag-1 expression gradually decreased from gastritis, IM, adenoma to carcinoma (P < .05), and negatively correlated with lymphatic invasion or lymph node metastasis, cytoplasmic Bag-1 expression, negative parafibromin expression, and poor prognosis (P < .05). Cytoplasmic Bag-1 was weakly immunoreactive in carcinomas, compared with gastritis (P < .05), and positively associated with invasive depth and poor prognosis of the carcinoma (P < .05). The positive rate of Bag-1 mRNA expression was higher in adjacent IMs than carcinomas or adjacent NNM (P < .05). Bag-1 mRNA was expressed more in carcinomas from female patients than the male counterparts (P < .05). There was a positive correlation of Bag-1 mRNA expression with invasive depth and venous invasion (P < .05). Our study indicated that aberrant expression and subcellular distribution of Bag-1 might play an important role in the malignant transformation of gastric epithelial cells and should be considered as a biomarker for gastric carcinogenesis, subsequent progression, and prognosis. |
| Author | Xu, Xiao-yan, PhD Wei, Zheng-li, MD, PhD Xing, Ya-nan, MD Takano, Yasuo, MD, PhD Masuda, Shinji, MD, PhD Zheng, Hua-chuan, MD, PhD Takahashi, Hiroyuki, MD, PhD |
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| Cites_doi | 10.1038/sj.onc.1201792 10.1016/S0895-4356(02)00534-6 10.1177/172460080702200203 10.1038/modpathol.3800165 10.1200/JCO.2001.19.4.992 10.1016/j.bbrc.2004.12.193 10.1007/s11055-008-0046-7 10.1046/j.1440-1827.2002.01342.x 10.1038/sj.onc.1202661 10.1097/00005537-200410000-00021 10.1080/00016340802087884 10.1006/excr.1998.4349 10.1007/s00428-007-0551-z 10.1046/j.1442-2050.2003.00307.x 10.1136/jcp.2006.038778 10.1093/emboj/19.23.6508 10.1038/sj.bjc.6604809 10.1016/S1368-8375(00)00025-7 10.1007/s00432-009-0599-z 10.1186/bcr1998 10.1038/sj.bjc.6600538 10.1002/1097-0215(20010920)95:5<317::AID-IJC1055>3.0.CO;2-J 10.1038/sj.onc.1202032 10.1002/pros.20384 10.1016/j.humpath.2007.11.009 10.1038/sj.bjc.6600579 10.1038/sj.bjc.6690805 10.1002/j.1460-2075.1996.tb01009.x 10.1002/path.1076 10.1016/j.oraloncology.2008.07.013 10.1186/1471-2407-4-85 |
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| Copyright | 2010 2015 INIST-CNRS Crown Copyright 2010. Published by Elsevier Inc. All rights reserved. Copyright Elsevier Limited May 2010 |
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| Keywords | Gastric carcinoma Bag-1 Prognosis Pathobiologic behavior Bag Malignant tumor Stomach cancer Stomach carcinoma Anatomic pathology Digestive diseases Evolution Behavior Localization Cytoplasm Cancer Gastric disease |
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| References | Kalinichenko, Matveeva (bib24) 2008; 38 Pagé, Côté, Rancourt, Sullivan, Piché (bib33) 2005; 328 Zheng, Takahashi, Murai (bib20) 2007; 60 Zheng, Takahashi, Li (bib23) 2008; 39 Bardelli, Longati, Albero (bib31) 1996; 15 Townsend, Cutress, Sharp, Brimmell, Packham (bib3) 2003; 1603 Schneikert, Hübner, Langer (bib25) 2000; 19 Yang, Hao, Ding, Pater, Tang (bib10) 1999; 5 Crabb, Hague, Johnson, Packham (bib32) 2008; 19 Yawata, Adachi, Okuda (bib29) 1998; 16 Kikuchi, Noguchi, Takeno, Funada, Moriyama, Uchida (bib16) 2002; 87 Yang, Chernenko, Hao (bib5) 1998; 17 Song, Kim, Lee (bib9) 2008; 87 Naishiro, Adachi, Okuda (bib30) 1999; 18 Turner, Krajewski, Krajewska (bib26) 2001; 19 Kelley, Duggan (bib1) 2003; 56 Zheng, Nakamura, Zheng (bib36) 2009; 135 Rorke, Murphy, Khalifa, Chernenko, Tang (bib12) 2001; 95 Millar, Anderson, McNeil (bib35) 2009; 100 Wood, Lee, Hague (bib6) 2009; 45 Krajewska, Turner, Shabaik, Krajewski, Reed (bib15) 2006; 66 Shindoh, Adachi, Higashino (bib8) 2000; 36 Götz, Kramer, Camarero, Rapp (bib7) 2004; 4 Vora, Mehta, Shah (bib13) 2007; 22 Sobin, Wittekind (bib19) 2002 Nadler, Camp, Giltnane (bib37) 2008; 10 Kumada, Tsuneyama, Hatta, Ishizawa, Takano (bib22) 2004; 17 Hague, Packham, Huntley, Shefford, Eveson (bib28) 2002; 197 Brimmell, Burns, Munson (bib34) 1999; 81 Zheng, Takahashi, Li, Masuda, Guan, Takano (bib18) 2008; 452 Li, Murai, Okada (bib21) 2002; 52 Yang, Hao, Ferenczy, Tang, Pater (bib11) 1999; 247 Ito, Yoshida, Nakano (bib14) 2003; 23 Cutress, Townsend, Brimmell, Bateman, Hague, Packham (bib4) 2002; 87 Zheng, Zheng, Li (bib2) 2008; 28 Noguchi, Takeno, Shibata (bib17) 2003; 16 Alper, Cukur, Belenli, Suna (bib27) 2008; 55 Xie, Clausen, Boysen (bib38) 2004; 114 Kikuchi (10.1016/j.humpath.2009.10.017_bib16) 2002; 87 Song (10.1016/j.humpath.2009.10.017_bib9) 2008; 87 Millar (10.1016/j.humpath.2009.10.017_bib35) 2009; 100 Kelley (10.1016/j.humpath.2009.10.017_bib1) 2003; 56 Sobin (10.1016/j.humpath.2009.10.017_bib19) 2002 Zheng (10.1016/j.humpath.2009.10.017_bib23) 2008; 39 Townsend (10.1016/j.humpath.2009.10.017_bib3) 2003; 1603 Shindoh (10.1016/j.humpath.2009.10.017_bib8) 2000; 36 Cutress (10.1016/j.humpath.2009.10.017_bib4) 2002; 87 Ito (10.1016/j.humpath.2009.10.017_bib14) 2003; 23 Rorke (10.1016/j.humpath.2009.10.017_bib12) 2001; 95 Zheng (10.1016/j.humpath.2009.10.017_bib18) 2008; 452 Naishiro (10.1016/j.humpath.2009.10.017_bib30) 1999; 18 Kumada (10.1016/j.humpath.2009.10.017_bib22) 2004; 17 Turner (10.1016/j.humpath.2009.10.017_bib26) 2001; 19 Wood (10.1016/j.humpath.2009.10.017_bib6) 2009; 45 Götz (10.1016/j.humpath.2009.10.017_bib7) 2004; 4 Schneikert (10.1016/j.humpath.2009.10.017_bib25) 2000; 19 Bardelli (10.1016/j.humpath.2009.10.017_bib31) 1996; 15 Yang (10.1016/j.humpath.2009.10.017_bib11) 1999; 247 Crabb (10.1016/j.humpath.2009.10.017_bib32) 2008; 19 Brimmell (10.1016/j.humpath.2009.10.017_bib34) 1999; 81 Zheng (10.1016/j.humpath.2009.10.017_bib36) 2009; 135 Li (10.1016/j.humpath.2009.10.017_bib21) 2002; 52 Vora (10.1016/j.humpath.2009.10.017_bib13) 2007; 22 Xie (10.1016/j.humpath.2009.10.017_bib38) 2004; 114 Pagé (10.1016/j.humpath.2009.10.017_bib33) 2005; 328 Kalinichenko (10.1016/j.humpath.2009.10.017_bib24) 2008; 38 Yang (10.1016/j.humpath.2009.10.017_bib5) 1998; 17 Krajewska (10.1016/j.humpath.2009.10.017_bib15) 2006; 66 Noguchi (10.1016/j.humpath.2009.10.017_bib17) 2003; 16 Zheng (10.1016/j.humpath.2009.10.017_bib2) 2008; 28 Nadler (10.1016/j.humpath.2009.10.017_bib37) 2008; 10 Alper (10.1016/j.humpath.2009.10.017_bib27) 2008; 55 Yawata (10.1016/j.humpath.2009.10.017_bib29) 1998; 16 Yang (10.1016/j.humpath.2009.10.017_bib10) 1999; 5 Zheng (10.1016/j.humpath.2009.10.017_bib20) 2007; 60 Hague (10.1016/j.humpath.2009.10.017_bib28) 2002; 197 |
| References_xml | – volume: 60 start-page: 273 year: 2007 end-page: 277 ident: bib20 article-title: Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray publication-title: J Clin Pathol contributor: fullname: Murai – volume: 39 start-page: 1042 year: 2008 end-page: 1049 ident: bib23 article-title: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas publication-title: contributor: fullname: Li – volume: 19 start-page: 689 year: 2008 end-page: 696 ident: bib32 article-title: BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells publication-title: Oncol Rep contributor: fullname: Packham – volume: 247 start-page: 200 year: 1999 end-page: 207 ident: bib11 article-title: Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer publication-title: Exp Cell Res contributor: fullname: Pater – volume: 15 start-page: 6205 year: 1996 end-page: 6212 ident: bib31 article-title: HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death publication-title: EMBO J contributor: fullname: Albero – volume: 87 start-page: 834 year: 2002 end-page: 839 ident: bib4 article-title: BAG-1 expression and function in human cancer publication-title: Br J Cancer contributor: fullname: Packham – volume: 56 start-page: 1 year: 2003 end-page: 9 ident: bib1 article-title: Gastric cancer epidemiology and risk factors publication-title: J Clin Epidemiol contributor: fullname: Duggan – volume: 45 start-page: 94 year: 2009 end-page: 102 ident: bib6 article-title: Bag-1 proteins in oral squamous cell carcinoma publication-title: Oral Oncol contributor: fullname: Hague – volume: 114 start-page: 1785 year: 2004 end-page: 1790 ident: bib38 article-title: Bag-1 expression as a prognostic factor in tongue squamous cell carcinomas publication-title: Laryngoscope contributor: fullname: Boysen – volume: 10 start-page: R35 year: 2008 ident: bib37 article-title: Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer publication-title: Breast Cancer Res contributor: fullname: Giltnane – volume: 18 start-page: 3244 year: 1999 end-page: 3251 ident: bib30 article-title: BAG-1 accelerates cell motility of human gastric cancer cells publication-title: Oncogene contributor: fullname: Okuda – volume: 38 start-page: 333 year: 2008 end-page: 344 ident: bib24 article-title: Morphological characteristics of apoptosis and its significance in neurogenesis publication-title: Neurosci Behav Physiol contributor: fullname: Matveeva – volume: 36 start-page: 444 year: 2000 end-page: 449 ident: bib8 article-title: BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma publication-title: Oral Oncol contributor: fullname: Higashino – volume: 135 start-page: 1521 year: 2009 end-page: 1532 ident: bib36 article-title: SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice publication-title: J Cancer Res Clin Oncol contributor: fullname: Zheng – volume: 16 start-page: 2681 year: 1998 end-page: 2686 ident: bib29 article-title: Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells publication-title: Oncogene contributor: fullname: Okuda – volume: 28 start-page: 2225 year: 2008 end-page: 2232 ident: bib2 article-title: Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma publication-title: Anticancer Res contributor: fullname: Li – volume: 95 start-page: 317 year: 2001 end-page: 322 ident: bib12 article-title: Prognostic significance of BAG-1 expression in nonsmall cell lung cancer publication-title: Int J Cancer contributor: fullname: Tang – volume: 197 start-page: 60 year: 2002 end-page: 71 ident: bib28 article-title: Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases publication-title: J Pathol contributor: fullname: Eveson – volume: 87 start-page: 1136 year: 2002 end-page: 1139 ident: bib16 article-title: Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas publication-title: Br J Cancer contributor: fullname: Uchida – year: 2002 ident: bib19 article-title: TNM Classification of Malignant Tumours contributor: fullname: Wittekind – volume: 1603 start-page: 83 year: 2003 end-page: 98 ident: bib3 article-title: BAG-1: a multifunctional regulator of cell growth and survival publication-title: Biochim Biophys Acta contributor: fullname: Packham – volume: 452 start-page: 147 year: 2008 end-page: 155 ident: bib18 article-title: Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas publication-title: Virchows Arch contributor: fullname: Takano – volume: 87 start-page: 862 year: 2008 end-page: 867 ident: bib9 article-title: BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer publication-title: Acta Obstet Gynecol Scand contributor: fullname: Lee – volume: 19 start-page: 6508 year: 2000 end-page: 6516 ident: bib25 article-title: Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor publication-title: EMBO J contributor: fullname: Langer – volume: 17 start-page: 981 year: 1998 end-page: 989 ident: bib5 article-title: Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells publication-title: Oncogene contributor: fullname: Hao – volume: 4 start-page: 85 year: 2004 ident: bib7 article-title: BAG-1 haplo-insufficiency impairs lung tumorigenesis publication-title: BMC Cancer contributor: fullname: Rapp – volume: 23 start-page: 569 year: 2003 end-page: 576 ident: bib14 article-title: Bag-1 expression in thyroid neoplasm: its correlation with Bcl-2 expression and carcinoma dedifferentiation publication-title: Anticancer Res contributor: fullname: Nakano – volume: 16 start-page: 107 year: 2003 end-page: 111 ident: bib17 article-title: Nuclear BAG-1 expression is a biomarker of poor prognosis in esophageal squamous cell carcinoma publication-title: Dis Esophagus contributor: fullname: Shibata – volume: 5 start-page: 1816 year: 1999 end-page: 1822 ident: bib10 article-title: Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues publication-title: Clin Cancer Res contributor: fullname: Tang – volume: 66 start-page: 801 year: 2006 end-page: 810 ident: bib15 article-title: Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers publication-title: Prostate contributor: fullname: Reed – volume: 328 start-page: 874 year: 2005 end-page: 884 ident: bib33 article-title: BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells publication-title: Biochem Biophys Res Commun contributor: fullname: Piché – volume: 81 start-page: 1042 year: 1999 end-page: 1051 ident: bib34 article-title: High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers publication-title: Br J Cancer contributor: fullname: Munson – volume: 100 start-page: 123 year: 2009 end-page: 133 ident: bib35 article-title: Butt. BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast publication-title: Br J Cancer contributor: fullname: McNeil – volume: 19 start-page: 992 year: 2001 end-page: 1000 ident: bib26 article-title: BAG-1: a novel biomarker predicting long- term survival in early-stage breast cancer publication-title: J Clin Oncol contributor: fullname: Krajewska – volume: 55 start-page: 1269 year: 2008 end-page: 1273 ident: bib27 article-title: Evaluation of the immunohistochemical stain patterns of surviving, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon publication-title: Hepatogastroenterology contributor: fullname: Suna – volume: 22 start-page: 100 year: 2007 end-page: 107 ident: bib13 article-title: Cytoplasmic localization of BAG-1 in leukoplakia and carcinoma of the tongue: correlation with p53 and c-erbB2 in carcinoma publication-title: Int J Biol Markers contributor: fullname: Shah – volume: 52 start-page: 234 year: 2002 end-page: 238 ident: bib21 article-title: Modified and simplified western blotting protocol: use of intermittent microwave irradiation (IMWI) and 5% skim milk to improve binding specificity publication-title: Pathol Int contributor: fullname: Okada – volume: 17 start-page: 1141 year: 2004 end-page: 1149 ident: bib22 article-title: Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital publication-title: Mod Pathol contributor: fullname: Takano – volume: 16 start-page: 2681 year: 1998 ident: 10.1016/j.humpath.2009.10.017_bib29 article-title: Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1201792 contributor: fullname: Yawata – volume: 56 start-page: 1 year: 2003 ident: 10.1016/j.humpath.2009.10.017_bib1 article-title: Gastric cancer epidemiology and risk factors publication-title: J Clin Epidemiol doi: 10.1016/S0895-4356(02)00534-6 contributor: fullname: Kelley – volume: 22 start-page: 100 year: 2007 ident: 10.1016/j.humpath.2009.10.017_bib13 article-title: Cytoplasmic localization of BAG-1 in leukoplakia and carcinoma of the tongue: correlation with p53 and c-erbB2 in carcinoma publication-title: Int J Biol Markers doi: 10.1177/172460080702200203 contributor: fullname: Vora – volume: 17 start-page: 1141 year: 2004 ident: 10.1016/j.humpath.2009.10.017_bib22 article-title: Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital publication-title: Mod Pathol doi: 10.1038/modpathol.3800165 contributor: fullname: Kumada – volume: 19 start-page: 992 year: 2001 ident: 10.1016/j.humpath.2009.10.017_bib26 article-title: BAG-1: a novel biomarker predicting long- term survival in early-stage breast cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.4.992 contributor: fullname: Turner – volume: 328 start-page: 874 year: 2005 ident: 10.1016/j.humpath.2009.10.017_bib33 article-title: BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.12.193 contributor: fullname: Pagé – year: 2002 ident: 10.1016/j.humpath.2009.10.017_bib19 contributor: fullname: Sobin – volume: 38 start-page: 333 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib24 article-title: Morphological characteristics of apoptosis and its significance in neurogenesis publication-title: Neurosci Behav Physiol doi: 10.1007/s11055-008-0046-7 contributor: fullname: Kalinichenko – volume: 52 start-page: 234 year: 2002 ident: 10.1016/j.humpath.2009.10.017_bib21 article-title: Modified and simplified western blotting protocol: use of intermittent microwave irradiation (IMWI) and 5% skim milk to improve binding specificity publication-title: Pathol Int doi: 10.1046/j.1440-1827.2002.01342.x contributor: fullname: Li – volume: 18 start-page: 3244 year: 1999 ident: 10.1016/j.humpath.2009.10.017_bib30 article-title: BAG-1 accelerates cell motility of human gastric cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1202661 contributor: fullname: Naishiro – volume: 114 start-page: 1785 year: 2004 ident: 10.1016/j.humpath.2009.10.017_bib38 article-title: Bag-1 expression as a prognostic factor in tongue squamous cell carcinomas publication-title: Laryngoscope doi: 10.1097/00005537-200410000-00021 contributor: fullname: Xie – volume: 1603 start-page: 83 year: 2003 ident: 10.1016/j.humpath.2009.10.017_bib3 article-title: BAG-1: a multifunctional regulator of cell growth and survival publication-title: Biochim Biophys Acta contributor: fullname: Townsend – volume: 87 start-page: 862 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib9 article-title: BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer publication-title: Acta Obstet Gynecol Scand doi: 10.1080/00016340802087884 contributor: fullname: Song – volume: 247 start-page: 200 year: 1999 ident: 10.1016/j.humpath.2009.10.017_bib11 article-title: Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer publication-title: Exp Cell Res doi: 10.1006/excr.1998.4349 contributor: fullname: Yang – volume: 452 start-page: 147 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib18 article-title: Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas publication-title: Virchows Arch doi: 10.1007/s00428-007-0551-z contributor: fullname: Zheng – volume: 16 start-page: 107 year: 2003 ident: 10.1016/j.humpath.2009.10.017_bib17 article-title: Nuclear BAG-1 expression is a biomarker of poor prognosis in esophageal squamous cell carcinoma publication-title: Dis Esophagus doi: 10.1046/j.1442-2050.2003.00307.x contributor: fullname: Noguchi – volume: 19 start-page: 689 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib32 article-title: BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells publication-title: Oncol Rep contributor: fullname: Crabb – volume: 60 start-page: 273 year: 2007 ident: 10.1016/j.humpath.2009.10.017_bib20 article-title: Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray publication-title: J Clin Pathol doi: 10.1136/jcp.2006.038778 contributor: fullname: Zheng – volume: 19 start-page: 6508 year: 2000 ident: 10.1016/j.humpath.2009.10.017_bib25 article-title: Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor publication-title: EMBO J doi: 10.1093/emboj/19.23.6508 contributor: fullname: Schneikert – volume: 100 start-page: 123 year: 2009 ident: 10.1016/j.humpath.2009.10.017_bib35 article-title: Butt. BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604809 contributor: fullname: Millar – volume: 36 start-page: 444 year: 2000 ident: 10.1016/j.humpath.2009.10.017_bib8 article-title: BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma publication-title: Oral Oncol doi: 10.1016/S1368-8375(00)00025-7 contributor: fullname: Shindoh – volume: 135 start-page: 1521 year: 2009 ident: 10.1016/j.humpath.2009.10.017_bib36 article-title: SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-009-0599-z contributor: fullname: Zheng – volume: 10 start-page: R35 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib37 article-title: Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer publication-title: Breast Cancer Res doi: 10.1186/bcr1998 contributor: fullname: Nadler – volume: 87 start-page: 834 year: 2002 ident: 10.1016/j.humpath.2009.10.017_bib4 article-title: BAG-1 expression and function in human cancer publication-title: Br J Cancer doi: 10.1038/sj.bjc.6600538 contributor: fullname: Cutress – volume: 95 start-page: 317 year: 2001 ident: 10.1016/j.humpath.2009.10.017_bib12 article-title: Prognostic significance of BAG-1 expression in nonsmall cell lung cancer publication-title: Int J Cancer doi: 10.1002/1097-0215(20010920)95:5<317::AID-IJC1055>3.0.CO;2-J contributor: fullname: Rorke – volume: 17 start-page: 981 year: 1998 ident: 10.1016/j.humpath.2009.10.017_bib5 article-title: Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1202032 contributor: fullname: Yang – volume: 66 start-page: 801 year: 2006 ident: 10.1016/j.humpath.2009.10.017_bib15 article-title: Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers publication-title: Prostate doi: 10.1002/pros.20384 contributor: fullname: Krajewska – volume: 39 start-page: 1042 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib23 article-title: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas publication-title: Hum Pathol doi: 10.1016/j.humpath.2007.11.009 contributor: fullname: Zheng – volume: 87 start-page: 1136 year: 2002 ident: 10.1016/j.humpath.2009.10.017_bib16 article-title: Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas publication-title: Br J Cancer doi: 10.1038/sj.bjc.6600579 contributor: fullname: Kikuchi – volume: 5 start-page: 1816 year: 1999 ident: 10.1016/j.humpath.2009.10.017_bib10 article-title: Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues publication-title: Clin Cancer Res contributor: fullname: Yang – volume: 23 start-page: 569 year: 2003 ident: 10.1016/j.humpath.2009.10.017_bib14 article-title: Bag-1 expression in thyroid neoplasm: its correlation with Bcl-2 expression and carcinoma dedifferentiation publication-title: Anticancer Res contributor: fullname: Ito – volume: 81 start-page: 1042 year: 1999 ident: 10.1016/j.humpath.2009.10.017_bib34 article-title: High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers publication-title: Br J Cancer doi: 10.1038/sj.bjc.6690805 contributor: fullname: Brimmell – volume: 15 start-page: 6205 year: 1996 ident: 10.1016/j.humpath.2009.10.017_bib31 article-title: HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death publication-title: EMBO J doi: 10.1002/j.1460-2075.1996.tb01009.x contributor: fullname: Bardelli – volume: 197 start-page: 60 year: 2002 ident: 10.1016/j.humpath.2009.10.017_bib28 article-title: Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases publication-title: J Pathol doi: 10.1002/path.1076 contributor: fullname: Hague – volume: 28 start-page: 2225 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib2 article-title: Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma publication-title: Anticancer Res contributor: fullname: Zheng – volume: 45 start-page: 94 year: 2009 ident: 10.1016/j.humpath.2009.10.017_bib6 article-title: Bag-1 proteins in oral squamous cell carcinoma publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2008.07.013 contributor: fullname: Wood – volume: 4 start-page: 85 year: 2004 ident: 10.1016/j.humpath.2009.10.017_bib7 article-title: BAG-1 haplo-insufficiency impairs lung tumorigenesis publication-title: BMC Cancer doi: 10.1186/1471-2407-4-85 contributor: fullname: Götz – volume: 55 start-page: 1269 year: 2008 ident: 10.1016/j.humpath.2009.10.017_bib27 article-title: Evaluation of the immunohistochemical stain patterns of surviving, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon publication-title: Hepatogastroenterology contributor: fullname: Alper |
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| Snippet | Summary Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis,... Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its... Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its... |
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| SubjectTerms | Adenoma - genetics Adenoma - metabolism Adenoma - pathology Apoptosis Bag-1 Behavior Biological and medical sciences Biomarkers, Tumor - metabolism Blotting, Western Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell cycle Cell Line Cell Nucleus - metabolism Cell Nucleus - pathology Cells, Cultured Cytoplasm - metabolism Cytoplasm - pathology Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gastric carcinoma Gastritis - genetics Gastritis - metabolism Gastritis - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Kinases Male Medical sciences Metaplasia - genetics Metaplasia - metabolism Metaplasia - pathology Multivariate analysis Pathobiologic behavior Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Proportional Hazards Models Proteins Reverse Transcriptase Polymerase Chain Reaction RNA polymerase RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Factors - genetics Transcription Factors - metabolism Tumors |
| Title | Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas |
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