HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay
Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O -dea...
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| Published in | Chemical science (Cambridge) Vol. 7; no. 3; pp. 2094 - 2099 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
CAMBRIDGE
Royal Soc Chemistry
01.03.2016
Royal Society of Chemistry |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative
O
-dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe
HKOCl-3
for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of
HKOCl-3
for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and
in vivo
imaging of live intact zebrafish embryos. Furthermore,
HKOCl-3
has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore,
HKOCl-3
holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. |
|---|---|
| AbstractList | Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative
-dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe
for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of
for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and
imaging of live intact zebrafish embryos. Furthermore,
has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore,
holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O -dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe HKOCl-3 for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of HKOCl-3 for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and in vivo imaging of live intact zebrafish embryos. Furthermore, HKOCl-3 has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore, HKOCl-3 holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O-dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe HKOCl-3 for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of HKOCl-3 for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and in vivo imaging of live intact zebrafish embryos. Furthermore, HKOCl-3 has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore, HKOCl-3 holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities.Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O-dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe HKOCl-3 for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of HKOCl-3 for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and in vivo imaging of live intact zebrafish embryos. Furthermore, HKOCl-3 has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore, HKOCl-3 holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. We describe an ultra-selective and ultra-sensitive HOCI fluorescent probe HKOCl-3 for live-cell and in vivo imaging and quantitative applications. Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O -dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe HKOCl-3 for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of HKOCl-3 for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and in vivo imaging of live intact zebrafish embryos. Furthermore, HKOCl-3 has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore, HKOCl-3 holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative O-dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe HKOCl-3 for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of HKOCl-3 for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and in vivo imaging of live intact zebrafish embryos. Furthermore, HKOCl-3 has been successfully applied to the detection of endogenous HOCl by a 96-well microplate assay and flow cytometry. Therefore, HKOCl-3 holds great promise as a versatile molecular tool that enables innovative investigation of HOCl biology and ROS-related diseases in multiple detection modalities. |
| Author | Hu, Jun Jacob Wong, Nai-Kei Ye, Sen Yi-Tsun Kao, Richard Lu, Ming-Yang Zhao, Angela Qian Shen, Jiangang Yang, Dan Gao, Peng Chen, Xingmiao |
| AuthorAffiliation | b School of Chinese Medicine , The University of Hong Kong , Pokfulam Road , Hong Kong , P. R. China a Morningside Laboratory for Chemical Biology and Department of Chemistry , The University of Hong Kong , Pokfulam Road , Hong Kong , P. R. China . Email: yangdan@hku.hk c Department of Microbiology , Research Center of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases , Pokfulam Road , Hong Kong , P. R. China |
| AuthorAffiliation_xml | – name: c Department of Microbiology , Research Center of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases , Pokfulam Road , Hong Kong , P. R. China – name: a Morningside Laboratory for Chemical Biology and Department of Chemistry , The University of Hong Kong , Pokfulam Road , Hong Kong , P. R. China . Email: yangdan@hku.hk – name: b School of Chinese Medicine , The University of Hong Kong , Pokfulam Road , Hong Kong , P. R. China |
| Author_xml | – sequence: 1 givenname: Jun Jacob surname: Hu fullname: Hu, Jun Jacob organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China – sequence: 2 givenname: Nai-Kei surname: Wong fullname: Wong, Nai-Kei organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China – sequence: 3 givenname: Ming-Yang surname: Lu fullname: Lu, Ming-Yang organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China – sequence: 4 givenname: Xingmiao surname: Chen fullname: Chen, Xingmiao organization: School of Chinese Medicine, The University of Hong Kong, P. R. China – sequence: 5 givenname: Sen surname: Ye fullname: Ye, Sen organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China – sequence: 6 givenname: Angela Qian surname: Zhao fullname: Zhao, Angela Qian organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China – sequence: 7 givenname: Peng surname: Gao fullname: Gao, Peng organization: Department of Microbiology, Research Center of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases, P. R. China – sequence: 8 givenname: Richard surname: Yi-Tsun Kao fullname: Yi-Tsun Kao, Richard organization: Department of Microbiology, Research Center of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases, P. R. China – sequence: 9 givenname: Jiangang surname: Shen fullname: Shen, Jiangang organization: School of Chinese Medicine, The University of Hong Kong, P. R. China – sequence: 10 givenname: Dan surname: Yang fullname: Yang, Dan organization: Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, P. R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29899935$$D View this record in MEDLINE/PubMed |
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| Snippet | Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed... We describe an ultra-selective and ultra-sensitive HOCI fluorescent probe HKOCl-3 for live-cell and in vivo imaging and quantitative applications.... |
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| SubjectTerms | Assaying Biology Chemistry Chemistry, Multidisciplinary Embryos Flow cytometry Fluorescence Laboratory apparatus Physical Sciences Robustness Science & Technology Zebrafish |
| Title | HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay |
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