Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1 - Lu, Yuhong; Liu, Yanfeng; Oeck, Sebastian; Glazer, Peter M. (Molecular cancer research, 2018)
Keywords: Animals; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell Survival - drug effects; Drug Resistance, Neoplasm - genetics; Epithelial-Mesenchymal Transition - drug effects; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - genetics; Gefitinib - administration & dosage; Gene Expression Regulation, Neoplastic - drug effects; Histone Demethylases - antagonists & inhibitors; Histone Demethylases - genetics; Humans; Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors; Jumonji Domain-Containing Histone Demethylases - genetics; Mice; Mutation; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Protein Kinase Inhibitors - administration & dosage; Repressor Proteins - antagonists & inhibitors; Repressor Proteins - genetics; Tumor Hypoxia - drug effects; Xenograft Model Antitumor Assays