Connective Tissue Abnormalities in Patients with Ruptured Intracranial Aneurysms and No Known Systemic Connective Tissue Disorder

• Published in: World neurosurgery Vol. 141; pp. e829 - e835
• Main Authors: Yerramilli, Sripartha Krishna, Kokula, Praneeth, Gupta, Sunil K., Radotra, Bishan D., Aggarwal, Ashish, Aggarwal, Divya, Chatterjee, Debajyoti
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2020
• Subjects: Adolescent; Adult; Biopsy; Case-Control Studies; Child; Connective Tissue - pathology; Connective Tissue Diseases - pathology; Connective tissue disorders; Ehlers-Danlos syndrome; Female; Humans; Internal elastic lamina; Intracranial Aneurysm - pathology; Intracranial aneurysms; Male; Marfan syndrome; Media; Middle Aged; Prospective Studies; Skin - pathology; Temporal Arteries - pathology; Young Adult; Connective tissue disorders; Internal elastic lamina; Intracranial aneurysms; IEL; STA; Ehlers-Danlos syndrome; EDS; MS; Media; IA; NF; Marfan syndrome

Defect in internal elastic lamina, defect in tunica media, and the amount of collagen and elastin play a role in vessel wall weakening leading to aneurysm formation. A similar picture may be found in connective tissue disorders, such as Marfan syndrome, Ehlers-Danlos syndrome (EDS), neurofibromatosi...