Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

• Published in: Human molecular genetics Vol. 19; no. 10; pp. 2059 - 2067
• Main Authors: Wang, Kai, Baldassano, Robert, Zhang, Haitao, Qu, Hui-Qi, Imielinski, Marcin, Kugathasan, Subra, Annese, Vito, Dubinsky, Marla, Rotter, Jerome I., Russell, Richard K., Bradfield, Jonathan P., Sleiman, Patrick M.A., Glessner, Joseph T., Walters, Thomas, Hou, Cuiping, Kim, Cecilia, Frackelton, Edward C., Garris, Maria, Doran, James, Romano, Claudio, Catassi, Carlo, Van Limbergen, Johan, Guthery, Stephen L., Denson, Lee, Piccoli, David, Silverberg, Mark S., Stanley, Charles A., Monos, Dimitri, Wilson, David C., Griffiths, Anne, Grant, Struan F.A., Satsangi, Jack, Polychronakos, Constantin, Hakonarson, Hakon
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.05.2010
• Subjects: Association Studies; Biological and medical sciences; Colitis, Ulcerative - genetics; Crohn Disease - genetics; Diabetes Mellitus, Type 1 - genetics; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Genetic Loci - genetics; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Humans; Inflammatory Bowel Diseases - genetics; Major Histocompatibility Complex - genetics; Medical sciences; Molecular and cellular biology; Other diseases. Semiology; Polymorphism, Single Nucleotide - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Endocrinopathy; Immunopathology; Crohn disease; Type 1 diabetes; Autoimmune disease; Genetics; Digestive diseases; Intestinal disease; Locus; Genetic determinism; Inflammatory disease; Ulcerative colitis

Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC), and type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility pathways. We examined known susceptibility loci for these diseases in a cohort of 1689 CD cases, 777 UC cases, 989 T1D c...