Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells

• Published in: Molecular cancer therapeutics Vol. 12; no. 8; pp. 1579 - 1590
• Main Authors: Filosto, Simone, Baston, David S, Chung, Samuel, Becker, Cathleen R, Goldkorn, Tzipora
• Format: Journal Article
• Language: English
• Published: United States 01.08.2013
• Subjects: Antineoplastic Agents - pharmacology; Carcinoma, Non-Small-Cell Lung - genetics; Cell Line, Tumor; Cell Survival - drug effects; Drug Resistance, Neoplasm - genetics; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms - genetics; Mutation; Phenotype; Phosphorylation; Protein Binding; Protein Kinase Inhibitors - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Smoking - adverse effects; src-Family Kinases - genetics; src-Family Kinases - metabolism; Transcriptional Activation

The EGF receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non-small cell lung carcinoma (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibitors (TKI) such as erlotinib. However, despite the efficacy observed in patients with NSCLC harboring...