Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

• Published in: Critical reviews in biochemistry and molecular biology Vol. 53; no. 3; pp. 311 - 334
• Main Authors: Kumar, Surinder, Lombard, David B.
• Format: Journal Article
• Language: English
• Published: England 01.06.2018
• Subjects: Animals; Citric Acid Cycle - genetics; Fatty Acids - genetics; Fatty Acids - metabolism; Glycolysis - genetics; Humans; Mitochondrial Proteins - antagonists & inhibitors; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Myocardium - enzymology; Neoplasms - drug therapy; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - enzymology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Reactive Oxygen Species - metabolism; Sirtuins - antagonists & inhibitors; Sirtuins - genetics; Sirtuins - metabolism; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; glutarylation; inhibitors; Succinylation; malonylation; mitochondria

Sirtuins are NAD -dependent protein deacylases/ADP-ribosyltransferases that have emerged as candidate targets for new therapeutics to treat metabolic disorders and other diseases, including cancer. The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negativel...