Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

• Published in: Cell metabolism Vol. 27; no. 6; pp. 1222 - 1235.e6
• Main Authors: Cignarella, Francesca, Cantoni, Claudia, Ghezzi, Laura, Salter, Amber, Dorsett, Yair, Chen, Lei, Phillips, Daniel, Weinstock, George M., Fontana, Luigi, Cross, Anne H., Zhou, Yanjiao, Piccio, Laura
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2018
• Subjects: Adipokines - blood; Adult; Animals; Autoimmunity; Bacteroidaceae - metabolism; Central Nervous System - immunology; diet; Encephalomyelitis, Autoimmune, Experimental - diet therapy; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - microbiology; experimental autoimmune encephalomyelitis; Fasting; Female; Gastrointestinal Microbiome; gut microbiota; Humans; intermittent fasting; Lactobacillaceae - metabolism; Mice; Mice, Inbred C57BL; Middle Aged; multiple sclerosis; Multiple Sclerosis - diet therapy; Multiple Sclerosis - immunology; Multiple Sclerosis - microbiology; Pilot Projects; T-Lymphocytes, Regulatory - immunology; Th17 Cells - immunology; intermittent fasting; experimental autoimmune encephalomyelitis; diet; multiple sclerosis; gut microbiota

Multiple sclerosis (MS) is more common in western countries with diet being a potential contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and pathology of the MS model, experimental autoimmune encephalomyelitis (EAE). IF led to increased gut bacteria richne...