Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA

• Published in: Clinical cancer research Vol. 27; no. 1; pp. 226 - 236
• Main Authors: Gao, ChongFeng, Wisniewski, Luke, Liu, Ying, Staal, Ben, Beddows, Ian, Plenker, Dennis, Aldakkak, Mohammed, Hall, Johnathan, Barnett, Daniel, Gouda, Mirna Kheir, Allen, Peter, Drake, Richard, Zureikat, Amer, Huang, Ying, Evans, Douglas, Singhi, Aatur, Brand, Randall E., Tuveson, David A., Tsai, Susan, Haab, Brian B.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Antigens, Tumor-Associated, Carbohydrate - blood; Antigens, Tumor-Associated, Carbohydrate - immunology; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biomarkers, Tumor - blood; Biomarkers, Tumor - immunology; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - mortality; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm - immunology; Humans; Inhibitory Concentration 50; Liquid Biopsy; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - immunology; Neoplasm Recurrence, Local - prevention & control; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - mortality; Polysaccharides - blood; Polysaccharides - immunology; Risk Assessment - methods
• ISSN: 1078-0432; 1557-3265; 1557-3265
• DOI: 10.1158/1078-0432.CCR-20-2475

A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. We hypothesized that a glycan biomarker for PDACs called sialylated tumor-related antigen (sTRA) could be used for this purpo...