Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 23; pp. 6924 - 6936
• Main Authors: Lin, Huai-Peng, Cheng, Zhou-Li, He, Ruo-Yu, Song, Lei, Tian, Meng-Xin, Zhou, Li-Sha, Groh, Beezly S., Liu, Wei-Ren, Ji, Min-Biao, Ding, Chen, Shi, Ying-Hong, Guan, Kun-Liang, Ye, Dan, Xiong, Yue
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Acetylation; Cell Growth Processes - genetics; Cell Proliferation; Fatty Acid Synthases - genetics; Humans; Lipogenesis - genetics; Signal Transduction; Tumor Microenvironment

Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN re...