Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs

• Published in: Journal of Immunology Vol. 178; no. 8; pp. 5192 - 5199
• Main Authors: Pompei, Luca, Jang, Sihyug, Zamlynny, Beata, Ravikumar, Sharada, McBride, Amanda, Hickman, Somia Perdow, Salgame, Padmini
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.04.2007
• Subjects: Animals; Dendritic Cells - immunology; Extracellular Signal-Regulated MAP Kinases - physiology; Interleukin-12 - biosynthesis; Interleukin-12 Subunit p40 - genetics; Macrophages - immunology; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Phosphatidylinositol 3-Kinases - physiology; Promoter Regions, Genetic; Toll-Like Receptor 2 - physiology; Toll-Like Receptor 9 - physiology; Tuberculosis - immunology

The control of IL-12 production from dendritic cells (DCs) and macrophages in response to Mycobacterium tuberculosis (Mtb) is not well understood. The objective of this study was to pursue the mechanism underlying our previous report that in response to Mtb infection, DCs release abundant IL-12, whe...