Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction

• Published in: Journal of cardiac failure Vol. 16; no. 7; pp. 556 - 561
• Main Authors: Chandrasekaran, Badrinathan, Kalra, Paul R., Donovan, Jackie, Hooper, James, Clague, Jonathon R., McDonagh, Theresa A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2010
• Subjects: Apelin; Biomarkers - blood; brain natriuretic peptide (BNP); Cardiovascular; Female; heart failure; Heart Failure - blood; Heart Failure - complications; Humans; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - blood; Intercellular Signaling Peptides and Proteins - deficiency; Male; Middle Aged; Myocardium - metabolism; Myocardium - pathology; Natriuretic Peptide, Brain - blood; Systole; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - complications; heart failure; brain natriuretic peptide (BNP); Apelin

Apelin is a novel endogenous peptide with inotropic and vasodilatory properties that is the ligand for the APJ receptor. Apelin and APJ are widely distributed in the vasculature of a number of organs and peripheral venous apelin is reduced in heart failure (HF). The location of apelin production in...