Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain

• Published in: Brain research. Developmental brain research Vol. 119; no. 1; pp. 139 - 153
• Main Authors: Ogunshola, Omolara O, Stewart, William B, Mihalcik, Vera, Solli, Todd, Madri, Joseph A, Ment, Laura R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 03.01.2000
• Subjects: Angiogenesis; Animals; Animals, Newborn; Cell Count; Cerebral Cortex - blood supply; Cerebral Cortex - growth & development; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Chronic Disease; Endothelial Growth Factors - biosynthesis; Endothelial Growth Factors - genetics; Gene Expression Regulation, Developmental; Glia; Glial Fibrillary Acidic Protein - metabolism; Hypoxia; Hypoxia, Brain - metabolism; Hypoxia, Brain - pathology; Lymphokines - biosynthesis; Lymphokines - genetics; Microcirculation - metabolism; Microcirculation - pathology; Neovascularization, Physiologic; Neuroglia - metabolism; Neuron; Neurons - cytology; Neurons - metabolism; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Rats; RNA, Messenger - metabolism; Stabilization; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Angiogenesis; Hypoxia; Neuron; Glia; Stabilization; Vascular endothelial growth factor

When exposed to chronic sublethal hypoxia the developing brain responds with increases in permeability and angiogenesis. Vascular endothelial growth factor (VEGF) may mediate this response. Here, we present data on the localization of VEGF in the rat brain cortex during postnatal development and its...