Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction

• Published in: Nucleic acids research Vol. 44; no. 8; pp. 3922 - 3935
• Main Authors: Klaus, Miriam, Prokoph, Nina, Girbig, Mathias, Wang, Xuecong, Huang, Yong-Heng, Srivastava, Yogesh, Hou, Linlin, Narasimhan, Kamesh, Kolatkar, Prasanna R, Francois, Mathias, Jauch, Ralf
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 05.05.2016
• Subjects: Animals; Cercopithecus aethiops; COS Cells; DNA - chemistry; DNA - metabolism; Gene Expression Regulation; Homeodomain Proteins - genetics; Mice; Nucleic Acid Conformation; Oligonucleotides; SOX Transcription Factors - chemistry; SOX Transcription Factors - metabolism; SOXF Transcription Factors - antagonists & inhibitors; SOXF Transcription Factors - chemistry; SOXF Transcription Factors - metabolism; Structural Biology; Transcription, Genetic; Tumor Suppressor Proteins - genetics

The transcription factor (TF) SOX18 drives lymphatic vessel development in both embryogenesis and tumour-induced neo-lymphangiogenesis. Genetic disruption of Sox18 in a mouse model protects from tumour metastasis and established the SOX18 protein as a molecular target. Here, we report the crystal st...