Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway - Kong, Ya-li; Shen, Yang; Ni, Jun; Shao, De-cui; Miao, Nai-jun; Xu, Jin-lan; Zhou, Li; Xue, Hong; Zhang, Wei; Wang, Xiao-xia; Lu, Li-min (Acta pharmacologica Sinica, 2016)
Keywords: Animals; Biomedical and Life Sciences; Biomedicine; Cell Line; Cell Proliferation; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Immunology; Insulin - metabolism; Insulin-Like Growth Factor I - metabolism; Internal Medicine; Kidney - metabolism; Kidney - pathology; Male; Medical Microbiology; Mesangial Cells - metabolism; Mesangial Cells - pathology; Original; original-article; Pharmacology/Toxicology; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1 - metabolism; Signal Transduction; Vaccine; 制剂; 处方; 药学; 药理; picropodophyllin; insulin deficiency; renal mesangial cells; IGF-1; IGF-1R; STZ rats; diabetic nephropathy