Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

• Published in: The Journal of biological chemistry Vol. 269; no. 47; pp. 29725 - 29731
• Main Authors: Kobayashi, K, Morita, S, Mizuguchi, T, Sawada, H, Yamada, K, Nagatsu, I, Fujita, K, Nagatsu, T
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 25.11.1994
• Subjects: Adrenal Glands - enzymology; Amino Acid Sequence; Animals; Base Sequence; Brain - enzymology; Catecholamines - metabolism; DNA, Complementary; Dopamine beta-Hydroxylase - biosynthesis; Dopamine beta-Hydroxylase - genetics; Dopamine beta-Hydroxylase - metabolism; Female; Humans; Male; Mice; Mice, Transgenic; Molecular Sequence Data

Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway. Transgenic mice were generated with multiple copies of a human DBH minigene construct containing the full-length cDNA...