Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons

• Published in: Neural regeneration research Vol. 15; no. 8; pp. 1539 - 1545
• Main Authors: Zhang, Yan, Fan, Bao-You, Pang, Yi-Lin, Shen, Wen-Yuan, Wang, Xu, Zhao, Chen-Xi, Li, Wen-Xiang, Liu, Chang, Kong, Xiao-Hong, Ning, Guang-Zhi, Feng, Shi-Qing, Yao, Xue
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.08.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Apoptosis; Biochemistry; Brain; Cell death; cystine/glutamate antiporter system light chain; deferoxamine; erastin; ferroptosis; glutathione peroxidase 4; neurons; neuroprotection; reactive oxygen species; Ferroptosis; Immunoglobulins; Laboratory animals; Nervous system; Neurons; Reactive oxygen species; Spinal cord; Spinal cord injuries; China; Beijing China; United States > US; erastin; glutathione peroxidase 4; deferoxamine; ferroptosis; neuroprotection; reactive oxygen species; neurons; cystine/glutamate antiporter system light chain

The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury. However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death. By comparing the survival rate and morphology of primary neurons and SH-SY5Y cells exposed to erastin, it was...