Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect

• Published in: Advanced healthcare materials Vol. 4; no. 6; pp. 892 - 902
• Main Authors: Chen, Yuan-I, Peng, Cheng-Liang, Lee, Pei-Chi, Tsai, Ming-Hsien, Lin, Chun-Yen, Shih, Ying-Hsia, Wei, Min-Feng, Luo, Tsai-Yueh, Shieh, Ming-Jium
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.04.2015; Wiley Subscription Services, Inc
• Subjects: amphiphilic copolymers; Animals; Cancer; Carbocyanines - chemistry; Chemotherapy; Drug delivery systems; Glycols; Imaging; laser-triggered; Lasers; Medical research; Mice; Mice, Nude; Micelles; Nanostructure; NIR fluorescence imaging; photothermal-chemotherapy; Self assembly; amphiphilic copolymers; laser-triggered; micelles; NIR fluorescence imaging; photothermal-chemotherapy

To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near‐infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)‐cyanine‐poly(ε‐caprolactone) (PCL) (mPEG‐Cy‐PCL) are synthesized. mPEG‐Cy‐PCL...