Dose‐ and time‐dependent effects of triethylene glycol dimethacrylate on the proteome of human THP‐1 monocytes

• Published in: European journal of oral sciences Vol. 126; no. 5; pp. 345 - 358
• Main Authors: Nilsen, Bo W., Simon‐Santamaria, Jaione, Örtengren, Ulf, Jensen, Einar, Bruun, Jack‐Ansgar, Michelsen, Vibeke B., Sørensen, Karen K.
• Format: Journal Article
• Language: English
• Published: England Wiley 01.10.2018; John Wiley and Sons Inc
• Subjects: Cell Culture Techniques; Cell Cycle - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Chromatography, Liquid; Dental Materials; Dentistry; DNA Damage; Dose-Response Relationship, Drug; Humans; isotope labeling; Materials Testing; Mitochondria - drug effects; Monocytes - drug effects; Odontologi; Original; Oxidative Stress; Polyethylene Glycols - toxicity; Polymethacrylic Acids - toxicity; Proteome; proteomics; Reactive Oxygen Species; Solvents; Tandem Mass Spectrometry; tandem mass spectroscopy; THP-1 Cells - drug effects; triethylene glycol dimethacrylate; tandem mass spectroscopy; triethylene glycol dimethacrylate; isotope labeling; proteomics; reactive oxygen species

Triethylene glycol dimethacrylate (TEGDMA) is commonly used in polymer resin‐based dental materials. This study investigated the molecular mechanisms of TEGDMA toxicity by identifying its time‐ and dose‐dependent effects on the proteome of human THP‐1 monocytes. The effects of different concentratio...