Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction

• Published in: Circulation (New York, N.Y.) Vol. 136; no. 1; pp. 6 - 19
• Main Authors: Obokata, Masaru, Reddy, Yogesh N.V., Pislaru, Sorin V., Melenovsky, Vojtech, Borlaug, Barry A.
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 04.07.2017
• Subjects: Aged; Aged, 80 and over; Cohort Studies; Exercise Test - methods; Female; Heart Failure - diagnosis; Heart Failure - epidemiology; Heart Failure - physiopathology; Hemodynamics - physiology; Humans; Male; Middle Aged; Obesity - diagnosis; Obesity - epidemiology; Obesity - physiopathology; Phenotype; Retrospective Studies; Stroke Volume - physiology; Ventricular Remodeling - physiology; hypertension, pulmonary; heart failure; exercise; pericardium; obesity

BACKGROUND:Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of treatment. Obesity is common in HFpEF and has many cardiovascular effects, suggesting that it may be a...