Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates - He, Qian; Mao, Qunying; An, Chaoqiang; Zhang, Jialu; Gao, Fan; Bian, Lianlian; Li, Changgui; Liang, Zhenglun; Xu, Miao; Wang, Junzhi (Emerging microbes & infections, 2021)
Keywords: Adenovirus Vaccines - administration & dosage; Adenovirus Vaccines - immunology; Adenoviruses; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Clinical trials; COVID-19 - prevention & control; COVID-19 vaccine; COVID-19 vaccines; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - immunology; Drug dosages; Food; Heterologous prime-boost; Immune response; Immunization, Secondary - methods; Interferon-gamma - blood; Lymphocyte Count; Lymphocytes; Mice; Mice, Inbred BALB C; mRNA Vaccines; neutralizing antibody; Pandemics; Peptides; Proteins; Public health; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; T cell response; T-Lymphocytes - immunology; T-Lymphocytes, Helper-Inducer - immunology; th1/th2 balance; Vaccination - adverse effects; Vaccines, Subunit - administration & dosage; Vaccines, Subunit - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Variance analysis; COVID-19 vaccine; neutralizing antibody; th1/th2 balance; Heterologous prime-boost; T cell response