Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models

• Published in: Reviews in medical virology Vol. 15; no. 5; pp. 327 - 345
• Main Authors: Tsutsui, Yoshihiro, Kosugi, Isao, Kawasaki, Hideya
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2005; Wiley Periodicals Inc
• Subjects: Animals; Brain - abnormalities; Brain - embryology; Brain - virology; Brain Diseases - pathology; Brain Diseases - virology; Cell Differentiation; Central Nervous System Viral Diseases - congenital; Central Nervous System Viral Diseases - pathology; Central Nervous System Viral Diseases - virology; Cytomegalovirus Infections - congenital; Cytomegalovirus Infections - pathology; Cytomegalovirus Infections - virology; Disease Models, Animal; Herpesviridae Infections - congenital; Herpesviridae Infections - pathology; Herpesviridae Infections - virology; Human cytomegalovirus; Mice; Muromegalovirus - pathogenicity; Muromegalovirus - physiology; Neuroglia - virology; Neurons - cytology; Neurons - virology; Stem Cells - cytology; Stem Cells - virology

Cytomegalovirus (CMV) is the most frequent infectious cause of developmental brain disorders and also causes brain damage in immunocompromised individuals. Although the brain is one of the main targets of CMV infection, little is known about the neuropathogenesis of the brain disorders caused by CMV...