Isaria cicadae conidia possess antiproliferative and inducing apoptosis properties in gynaecological carcinoma cells

Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, Isaria cicadae conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was...

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Published inMycology Vol. 8; no. 4; pp. 327 - 334
Main Authors Sun, Yan-fang, Sun, Yang, Wang, Zhi-an, Han, Rui-lian, Lu, Hong-fei, Zhang, Jia-lei, Liu, Hong-tao, Wang, Shi-xian, Wang, Pan, Dian, Lu-lu, Liang, Zong-suo
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.10.2017
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Annexin V
Anticancer properties
Apoptosis
Beauvericin
Breast cancer
Cancer
Conidia
Cordycepin
gynaecological carcinoma cells
Gynecological cancer
Gynecology
High performance liquid chromatography
high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology (UPLC-ESI-Q-TOF-MS)
Invited
Isaria cicadae
Isaria cicadae broken conidia powder (ICBCP)
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Mitochondria
mitochondrial apoptosis pathway
Physical characteristics
Quadrupoles
Staining
Isaria cicadae
Isaria cicadae broken conidia powder (ICBCP)
mitochondrial apoptosis pathway
gynaecological carcinoma cells
high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology (UPLC-ESI-Q-TOF-MS)
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Abstract Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, Isaria cicadae conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of Isaria cicadae conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells. Isaria cicadae conidia were identified by UPLC-ESI-Q-TOF-MS: high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology. Eight main compounds were identified which are nucleosides, cordycepic acid, cordycepin, beauvericin and myriocin by MS fragmentation ions. The nuclear morphology indicated the typical characteristics of apoptosis by Hoechst staining. Annexin V/PI staining revealed that the number of apoptotic cells was increased by Isaria cicadae conidia treatment. Furthermore, Isaria cicadae conidia also induced the caspase-mediated mitochondrial apoptosis pathway. The findings suggest that the full-scale active ingredients highlight the significance of Isaria cicadae conidia as potential anti-cancer agent in China.
AbstractList Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, Isaria cicadae conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of Isaria cicadae conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells. Isaria cicadae conidia were identified by UPLC-ESI-Q-TOF-MS: high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology. Eight main compounds were identified which are nucleosides, cordycepic acid, cordycepin, beauvericin and myriocin by MS fragmentation ions. The nuclear morphology indicated the typical characteristics of apoptosis by Hoechst staining. Annexin V/PI staining revealed that the number of apoptotic cells was increased by Isaria cicadae conidia treatment. Furthermore, Isaria cicadae conidia also induced the caspase-mediated mitochondrial apoptosis pathway. The findings suggest that the full-scale active ingredients highlight the significance of Isaria cicadae conidia as potential anti-cancer agent in China.
is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells. conidia were identified by UPLC-ESI-Q-TOF-MS: high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology. Eight main compounds were identified which are nucleosides, cordycepic acid, cordycepin, beauvericin and myriocin by MS fragmentation ions. The nuclear morphology indicated the typical characteristics of apoptosis by Hoechst staining. Annexin V/PI staining revealed that the number of apoptotic cells was increased by conidia treatment. Furthermore, conidia also induced the caspase-mediated mitochondrial apoptosis pathway. The findings suggest that the full-scale active ingredients highlight the significance of conidia as potential anti-cancer agent in China.
Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, Isaria cicadae conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of Isaria cicadae conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells. Isaria cicadae conidia were identified by UPLC-ESI-Q-TOF-MS: high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology. Eight main compounds were identified which are nucleosides, cordycepic acid, cordycepin, beauvericin and myriocin by MS fragmentation ions. The nuclear morphology indicated the typical characteristics of apoptosis by Hoechst staining. Annexin V/PI staining revealed that the number of apoptotic cells was increased by Isaria cicadae conidia treatment. Furthermore, Isaria cicadae conidia also induced the caspase-mediated mitochondrial apoptosis pathway. The findings suggest that the full-scale active ingredients highlight the significance of Isaria cicadae conidia as potential anti-cancer agent in China.
Author Wang, Zhi-an
Zhang, Jia-lei
Han, Rui-lian
Lu, Hong-fei
Liang, Zong-suo
Liu, Hong-tao
Wang, Pan
Dian, Lu-lu
Sun, Yang
Sun, Yan-fang
Wang, Shi-xian
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Cites_doi 10.1016/j.etap.2016.02.009
10.1016/S0378-8741(02)00212-X
10.1002/path.1711420112
10.1038/35037710
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Keywords Isaria cicadae
Isaria cicadae broken conidia powder (ICBCP)
mitochondrial apoptosis pathway
gynaecological carcinoma cells
high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology (UPLC-ESI-Q-TOF-MS)
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Snippet Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer....
is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, conidia for...
Isaria cicadae is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer....
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SubjectTerms Annexin V
Anticancer properties
Apoptosis
Beauvericin
Breast cancer
Cancer
Conidia
Cordycepin
gynaecological carcinoma cells
Gynecological cancer
Gynecology
High performance liquid chromatography
high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology (UPLC-ESI-Q-TOF-MS)
Invited
Isaria cicadae
Isaria cicadae broken conidia powder (ICBCP)
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Mitochondria
mitochondrial apoptosis pathway
Physical characteristics
Quadrupoles
Staining
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Title Isaria cicadae conidia possess antiproliferative and inducing apoptosis properties in gynaecological carcinoma cells
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