Tachykinins as mediators of slow EPSPs in guinea-pig gall-bladder ganglia: involvement of neurokinin-3 receptors
1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated with single-electrode voltage- and current-clamp recording techniques. 2. Pressure ejection of substance P (100 microM) caused a long lasting membrane depolarization that was as...
Saved in:
Published in | The Journal of physiology Vol. 485; no. Pt 2; pp. 513 - 524 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
England
The Physiological Society
01.06.1995
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | 1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated
with single-electrode voltage- and current-clamp recording techniques. 2. Pressure ejection of substance P (100 microM) caused
a long lasting membrane depolarization that was associated with a decrease in input resistance. In cells that were voltage-clamped
to their resting membrane potential, substance P activated an inward current. 3. The reversal potentials of the substance
P-induced depolarization and inward current were congruent to 0 mV. In a low-Na+ solution, the substance P-induced depolarization
and inward current were reduced in amplitude. 4. Substance P increased the excitability of neurones, as evidenced by a greater
anodal break activity and an increase in the number of action potentials generated during a depolarizing current pulse. 5.
Substance P, neurokinin A (NKA) and neurokinin B (NKB) were applied by superfusion to determine the relative potencies of
these tachykinins. NKB was the most potent, with an EC50 of 24 nM. The EC50 values for NKA and substance P were 47.8 and 281
nM, respectively. 6. The neurokinin-3 (NK-3) receptor agonist senktide depolarized neurones with an EC50 of 6.3 nM. Neither
the NK-1 receptor agonist [Sar9,Met(O2)11]-substance P nor the NK-2 receptor agonist [beta-Ala8]-NKA(4-10) caused a measurable
depolarization. 7. The NK-3 antagonist [Trp7,beta-Ala8]-NKA (4-10) inhibited the responsiveness of gall-bladder neurones to
substance P with a KB (dissociation constant of receptor antagonist) of 49 nM, and depressed both capsaicin-induced depolarizations
and stimulus-evoked slow EPSPs. 8. These data indicate that tachykinins mediate slow EPSPs in guinea-pig gall-bladder ganglia
by activating NK-3 receptors on gall-bladder neurones. It is proposed that in response to inflammation or high intraluminal
pressure, tachykinins may be released within ganglia by sensory fibres and act directly on intrinsic neurones to facilitate
ganglionic transmission. |
---|---|
AbstractList | 1. The effects of endogenous tachykinins and related peptides on intact guinea‐pig gall‐bladder neurones were investigated with single‐electrode voltage‐ and current‐clamp recording techniques. 2. Pressure ejection of substance P (100 microM) caused a long lasting membrane depolarization that was associated with a decrease in input resistance. In cells that were voltage‐clamped to their resting membrane potential, substance P activated an inward current. 3. The reversal potentials of the substance P‐induced depolarization and inward current were congruent to 0 mV. In a low‐Na+ solution, the substance P‐induced depolarization and inward current were reduced in amplitude. 4. Substance P increased the excitability of neurones, as evidenced by a greater anodal break activity and an increase in the number of action potentials generated during a depolarizing current pulse. 5. Substance P, neurokinin A (NKA) and neurokinin B (NKB) were applied by superfusion to determine the relative potencies of these tachykinins. NKB was the most potent, with an EC50 of 24 nM. The EC50 values for NKA and substance P were 47.8 and 281 nM, respectively. 6. The neurokinin‐3 (NK‐3) receptor agonist senktide depolarized neurones with an EC50 of 6.3 nM. Neither the NK‐1 receptor agonist [Sar9,Met(O2)11]‐substance P nor the NK‐2 receptor agonist [beta‐Ala8]‐NKA(4‐10) caused a measurable depolarization. 7. The NK‐3 antagonist [Trp7,beta‐Ala8]‐NKA (4‐10) inhibited the responsiveness of gall‐bladder neurones to substance P with a KB (dissociation constant of receptor antagonist) of 49 nM, and depressed both capsaicin‐induced depolarizations and stimulus‐evoked slow EPSPs. 8. These data indicate that tachykinins mediate slow EPSPs in guinea‐pig gall‐bladder ganglia by activating NK‐3 receptors on gall‐bladder neurones. It is proposed that in response to inflammation or high intraluminal pressure, tachykinins may be released within ganglia by sensory fibres and act directly on intrinsic neurones to facilitate ganglionic transmission. 1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated with single-electrode voltage- and current-clamp recording techniques. 2. Pressure ejection of substance P (100 microM) caused a long lasting membrane depolarization that was associated with a decrease in input resistance. In cells that were voltage-clamped to their resting membrane potential, substance P activated an inward current. 3. The reversal potentials of the substance P-induced depolarization and inward current were congruent to 0 mV. In a low-Na+ solution, the substance P-induced depolarization and inward current were reduced in amplitude. 4. Substance P increased the excitability of neurones, as evidenced by a greater anodal break activity and an increase in the number of action potentials generated during a depolarizing current pulse. 5. Substance P, neurokinin A (NKA) and neurokinin B (NKB) were applied by superfusion to determine the relative potencies of these tachykinins. NKB was the most potent, with an EC50 of 24 nM. The EC50 values for NKA and substance P were 47.8 and 281 nM, respectively. 6. The neurokinin-3 (NK-3) receptor agonist senktide depolarized neurones with an EC50 of 6.3 nM. Neither the NK-1 receptor agonist [Sar9,Met(O2)11]-substance P nor the NK-2 receptor agonist [beta-Ala8]-NKA(4-10) caused a measurable depolarization. 7. The NK-3 antagonist [Trp7,beta-Ala8]-NKA (4-10) inhibited the responsiveness of gall-bladder neurones to substance P with a KB (dissociation constant of receptor antagonist) of 49 nM, and depressed both capsaicin-induced depolarizations and stimulus-evoked slow EPSPs. 8. These data indicate that tachykinins mediate slow EPSPs in guinea-pig gall-bladder ganglia by activating NK-3 receptors on gall-bladder neurones. It is proposed that in response to inflammation or high intraluminal pressure, tachykinins may be released within ganglia by sensory fibres and act directly on intrinsic neurones to facilitate ganglionic transmission. |
Author | G M Mawe |
AuthorAffiliation | Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington 05405, USA |
AuthorAffiliation_xml | – name: Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington 05405, USA |
Author_xml | – sequence: 1 givenname: G M surname: Mawe fullname: Mawe, G M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7545233$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkd1v0zAUxS00NLrBnwDKE0JIKb7-iBMekGAaX5pEJcqz5aY3iYdrZ3bTqv89Ce0meEE8WfY55-d7dS7ImQ8eCXkBdA4A_M1t3x2SDW4OVSXnqaeMKqEekRmIosqVqvgZmVHKWM6VhCfkIqVbSoHTqjon50oKyTifkX5p6u7w03rrU2ZStsG1NdsQUxaaLLmwz64X3xcpsz5rB-vR5L1ts9Y4l6-cWa8xjhffOmvejp5dcDvcoN9OaY9DDL_JOc8i1thP3KfkcWNcwmen85L8-Hi9vPqc33z79OXq_U1eC6V4Xq5UyRoQ1JRCSoZVBZQptSoQ61oUBQAVXIFYM0lRUsYlbxqsAQpDleScX5J3R24_rMal6nGoaJzuo92YeNDBWP234m2n27DTALKkQEfAyxMghrsB01ZvbKrROeMxDEkrJaqyUtNPr_5phHEeoQrF5GgtjtY6hpQiNg_zANVTrfq-Vj3Vqu9rHYPP_9zmIXbqcdQ_HPW9dXj4T6pefl1MD6KUTMIEeX2EdLbt9jaiPsZSqC1uD3r06cVWMz2ZfwH4sse2 |
CitedBy_id | crossref_primary_10_1038_sj_bjp_0701560 crossref_primary_10_1111_j_1365_2982_2004_00501_x crossref_primary_10_1002_ar_a_20089 crossref_primary_10_1016_S0306_4522_96_00625_2 crossref_primary_10_1164_ajrccm_158_1_9705052 crossref_primary_10_1016_S0016_5085_03_00694_2 crossref_primary_10_1016_S1566_0702_02_00003_6 crossref_primary_10_1152_ajpgi_2001_281_2_G357 crossref_primary_10_1113_jphysiol_2005_083493 crossref_primary_10_1152_physiologyonline_1998_13_2_84 crossref_primary_10_1152_ajpregu_00001_2002 crossref_primary_10_1111_j_1469_7793_1999_0533t_x crossref_primary_10_1038_sj_bjp_0705704 crossref_primary_10_1152_ajpgi_1997_273_5_G1127 crossref_primary_10_1002_ar_1088 crossref_primary_10_1016_S0306_4522_01_00064_1 crossref_primary_10_1038_sj_bjp_0703278 crossref_primary_10_3389_fped_2024_1360420 crossref_primary_10_1038_sj_bjp_0706066 crossref_primary_10_3389_fimmu_2016_00140 crossref_primary_10_1016_S0306_4522_01_00583_8 crossref_primary_10_1046_j_1365_2982_2003_00417_x crossref_primary_10_1016_j_ejphar_2004_07_020 crossref_primary_10_1016_j_jaci_2013_11_027 crossref_primary_10_1016_S0014_2999_01_01505_9 crossref_primary_10_1016_S0165_1838_96_00081_1 crossref_primary_10_1046_j_1365_2036_2000_014s2002_x crossref_primary_10_1016_S0167_0115_00_00177_4 crossref_primary_10_1002__SICI_1097_0029_19971001_39_1_1__AID_JEMT1_3_0_CO_2_R crossref_primary_10_1016_S0003_9969_99_00031_X crossref_primary_10_1124_jpet_300_1_314 crossref_primary_10_1016_j_neuroscience_2004_03_021 crossref_primary_10_1152_ajpregu_2001_281_6_R1792 crossref_primary_10_1152_ajpgi_00521_2007 crossref_primary_10_1002_1097_0185_20010101_262_1_101__AID_AR1015_3_0_CO_2_1 crossref_primary_10_1152_ajpgi_2000_279_3_G622 crossref_primary_10_1111_j_1469_7793_1997_065bf_x crossref_primary_10_1152_ajpgi_1998_274_3_G493 |
ContentType | Journal Article |
Copyright | 1995 The Physiological Society |
Copyright_xml | – notice: 1995 The Physiological Society |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 7X8 5PM |
DOI | 10.1113/jphysiol.1995.sp020747 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Neurosciences Abstracts MEDLINE - Academic |
DatabaseTitleList | CrossRef Neurosciences Abstracts MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1469-7793 |
EndPage | 524 |
ExternalDocumentID | 10_1113_jphysiol_1995_sp020747 7545233 TJP19954852513 485_Pt_2_513 |
Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
GrantInformation_xml | – fundername: NINDS NIH HHS grantid: NS 26995 |
GroupedDBID | - 08R 0YM 1OB 1OC 24P 29L 2WC 33P 3EH 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52T 52U 52V 52W 52X 53G 55 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM AAESR AAYJJ ABFLS ABITZ ABIVO ABOCM ABPPZ ABPTK ABUFD ACGFS ACIWK ACNCT ACPRK ADACO ADBBV ADZMN AEUQT AFBPY AFFNX ALAGY ALMA_UNASSIGNED_HOLDINGS AMBMR ATUGU BAFTC BAWUL BY8 CS3 D-6 D-7 D-E D-F DCZOG DIK DR2 DRMAN DZ E3Z EBS EJD F00 F01 F04 F20 F5P FA8 FIJ GA GJ GX1 H.X H13 H~9 IX1 J0M LATKE LC2 LC3 LI0 LW6 LYRES MK4 MRFUL MVM N04 N05 N9A NEJ NF O0- O66 OHM OHT OK1 P2P P2W P2X P2Z P4A Q.N RIG RPM RX1 SUPJJ TLM TN5 UPT UQL V8K VH1 W8V W99 WBKPD WH7 WIH WIJ WIN WNSPC WOQ WRC WT WXI X X7M YZZ ZA5 ZGI ZXP ZY4 --- -DZ -~X .55 .GJ 18M 36B AAFWJ ABCQN ABEML ABJNI ACGFO ACPOU ACSCC ADKYN ADOZA AEGXH AFEBI AI. AIAGR AOIJS IPNFZ K48 LEEKS NF~ OIG SAMSI TR2 W8F WXSBR XOL YQT ~WT CGR CUY CVF ECM EIF NPM .3N .GA .Y3 05W 0R~ 10A 123 31~ 52S 930 A01 A03 AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAYXX AAZKR ABCUV ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGOF ACMXC ACXBN ACXQS ADBTR ADEOM ADIZJ ADMGS ADXAS AEEZP AEIGN AEIMD AEQDE AEUYR AFFPM AFGKR AFPWT AFZJQ AHBTC AIACR AITYG AIURR AIWBW AJBDE ALUQN AMYDB AZBYB AZVAB BFHJK BHBCM BMXJE BROTX BRXPI C1A C45 CAG CHEAL CITATION COF DPXWK DRFUL DRSTM EMOBN EX3 FUBAC G-S G.N GODZA HF~ HGLYW HZI HZ~ IHE KBYEO LH4 LITHE LOXES LP6 LP7 LUTES MEWTI MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM O9- OVD P4B P4D Q11 QB0 R.K ROL TEORI UB1 UKR WHG WIK WOHZO WOW WQJ WYISQ XG1 YBU YHG YKV YSK YXB YYP ZZTAW ~IA 7TK 7X8 5PM |
ID | FETCH-LOGICAL-c4773-8b782f140a84552e9910277b6eecc46611043714d250e502353ffec116a075333 |
IEDL.DBID | RPM |
ISSN | 0022-3751 |
IngestDate | Tue Sep 17 21:17:12 EDT 2024 Sat Aug 17 00:10:54 EDT 2024 Fri Aug 16 12:15:32 EDT 2024 Fri Aug 23 00:58:13 EDT 2024 Thu May 23 23:52:51 EDT 2024 Sat Aug 24 00:59:20 EDT 2024 Fri Jan 15 02:13:32 EST 2021 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Pt 2 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4773-8b782f140a84552e9910277b6eecc46611043714d250e502353ffec116a075333 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1158010 |
PMID | 7545233 |
PQID | 1753476725 |
PQPubID | 23462 |
PageCount | 12 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_1158010 proquest_miscellaneous_77498973 proquest_miscellaneous_1753476725 crossref_primary_10_1113_jphysiol_1995_sp020747 pubmed_primary_7545233 wiley_primary_10_1113_jphysiol_1995_sp020747_TJP19954852513 highwire_physiosociety_485_Pt_2_513 |
PublicationCentury | 1900 |
PublicationDate | June 1, 1995 |
PublicationDateYYYYMMDD | 1995-06-01 |
PublicationDate_xml | – month: 06 year: 1995 text: June 1, 1995 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | The Journal of physiology |
PublicationTitleAlternate | J Physiol |
PublicationYear | 1995 |
Publisher | The Physiological Society |
Publisher_xml | – name: The Physiological Society |
SSID | ssj0013099 |
Score | 1.7301842 |
Snippet | 1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated
with single-electrode voltage- and... 1. The effects of endogenous tachykinins and related peptides on intact guinea‐pig gall‐bladder neurones were investigated with single‐electrode voltage‐ and... 1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated with single-electrode voltage- and... |
SourceID | pubmedcentral proquest crossref pubmed wiley highwire |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 513 |
SubjectTerms | Animals Electric Stimulation Evoked Potentials - drug effects Female Gallbladder - innervation Gallbladder - physiology Ganglia, Autonomic - cytology Ganglia, Autonomic - physiology Guinea Pigs In Vitro Techniques Male Membrane Potentials - drug effects Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Receptors, Neurokinin-3 - drug effects Sodium - physiology Substance P - pharmacology Synapses - drug effects Synapses - physiology Tachykinins - agonists Tachykinins - antagonists & inhibitors Tachykinins - pharmacology |
Title | Tachykinins as mediators of slow EPSPs in guinea-pig gall-bladder ganglia: involvement of neurokinin-3 receptors |
URI | http://jp.physoc.org/content/485/Pt_2/513.abstract https://onlinelibrary.wiley.com/doi/abs/10.1113%2Fjphysiol.1995.sp020747 https://www.ncbi.nlm.nih.gov/pubmed/7545233 https://search.proquest.com/docview/1753476725 https://search.proquest.com/docview/77498973 https://pubmed.ncbi.nlm.nih.gov/PMC1158010 |
Volume | 485 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Rb9MwELa2SUh7QYMxERjDCMSbl7i24wSepmnTGBqKRCftzXJcpyu0SbS0Qv33nJ24ogIkxGMS52LnzvZ39t1nhN4BaJPWSE0mVKaEZ8aQkuclmUhbVQktU6Nd7vDNl_Tqll_fibsdJEIujA_aN-XstJ4vTuvZvY-tbBcmDnFicXFzDigGBtYk3kW7krHgooetgyTPNxThUtAhLZhSFn_zqwXN3KXoCeixAJUATe-jR9KdtM3Y9twU-IL_hD1_D6H8Fdr6uenyAD0eQCU-6yv_BO3Y-ik6PKvBoV6s8Xtc9BVqputD1I61uV9_d-dCdFh32KeOuCN3cFPhbt78wBfF16LDsxpPVwBBNWlnU-z250k5d8PUA1y43F_9AcrA4OYJx5fubc-N6SUThmEkta2T-wzdXl6Mz6_IcOwCMVxKRrISUEMFjpfOuBAjCwjSbfSWqQV1c5jPqeNDonwC6MkKx5fDXOgJpakG_MEYO0J7dVPb5wgnspKiKlkGorjmNjfGCMGMSXmaVKmMUBx-uGp7dg3VeyVMBWUppywVlBWht0Evqi_Q9dGtimdCFUs1UoKyCL0JKlPQXdweiK5ts-qUIyblMpUjEaHXfykDiDjPcglSjnolb-o22EmE5Jb2N88dV_f2EzBhz9k9mGyEPno7-cfWqvF14W5A2wCHshf__d2XaL_PxXfLR8dob_mwsq8ATS3LE_AjPn0-8X3oJ1nrIF8 |
link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFL0aQ4i98DUmwoAZgXhL29R2nMDTNG0qY50i0aG9WYnrdGVtUi2ppvLruXbiivIhAY-JHSdXPnbOte89BniLpE1oJVJ_HIjQZ5FSfsbizB8Lnee9IAtVanKHh-fh4IKdXvLLLeAuF8YG7ats2ilm804xvbKxlYu56ro4sW4yPEIWgxNrr3sH7uJ47QvnpLvNg14cr0XCBQ_axOAgoN2vdr2gnJkkPY5jFskS8ukduCfMWduUbv6dnGLw79jnr0GUP5Jb-3c6eQhfnF1NUMp1Z1lnHfXtJ8nHfzb8ETxo-So5bIofw5YunsDuYYG--nxF3pGksbScrHZhMUrV1eraHDlRkbQiNivFnOZDypxUs_KWHCefk4pMCzJZIrtN_cV0QszWv5_NzAx4gxcmrTh9j3Vw3rRa5rV52spu2pZ9SnCS1gvT7lO4ODkeHQ389kQHXzEhqB9lSEhy9OnSiHHe10hOzR5yFmpEEkOqEBippYCNkZhpbqR4qIlqCYIwRWpDKd2D7aIs9DMgPZELnmc0wqZYynSslOKcKhWysJeHwoOu60m5aIQ7ZOPwUOlQIA0KpEOBB29ch8umQtUEzkoWcZnUsi95QD147bAgcSSa7ZW00OWykkbzlIlQ9LkHB3-og2Q7jmKBrew16Fl_WwtAD8QGrNblRgZ8swRBYuXAW1B48MEC8C-tlaPTxNxA25Di0uf__d4DuD8YDc_k2cfzT_uw06T8m1WqF7Bd3yz1SyRtdfbKDtHvp55BTg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFD6CIdBeuI2JcJsRiLc0SW3HCTxNY9UYbIpEJ028WInrdGVtEi2pUPn1HDtJtXKR0B6TOE6O_Nn-bJ_zHYC3SNqEViJ1J4EIXRYp5WYsztyJ0HnuB1moUhM7fHIaHp2x43N-fi3Vl3XaV9lsUMwXg2J2YX0rq4Xyej8xLzk5QBaDA6vvVZPcuw13sM8O436h3h8g-HG8FgoXPOiCg4OAet_tnkE5N4F6HPstEibk1NtwV5h825RuzlC9avDfGOifjpTXCa6doUYP4FtvW-uYcjlYNtlA_fxN9vFGxj-E-x1vJfttkUdwSxePYWe_wDX7YkXekaS1tpyudqAap-pidWlST9QkrYmNTjFZfUiZk3pe_iCHydekJrOCTJfIclO3mk2JcQFws7kZCa_wwoQXp--xDI6fVtO8MW9b-U1bs0sJDta6MvU-gbPR4fjgyO0yO7iKCUHdKENikuPaLo0Y50ONJNWcJWehRkQxpAyBkVwK2AQJmuZGkoca75YgCFOkOJTSXdgqykI_BeKLXPA8oxFWxVKmY6UU51SpkIV-HgoHvL41ZdUKeMh24UNljwRpkCB7JDjwpm902RaoWwdaySIuk0YOJQ-oA697PEjskeaYJS10uayl0T5lIhRD7sDeP8og6Y6jWGAtuy2C1v_WgdABsQGt9XMjB775BIFiZcE7YDjwwYLwP62V4-PE3EDbkOrSZzf-7h7cSz6O5JdPp5-fw3Yb-W82q17AVnO11C-RuzXZK9tLfwGnH0PO |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tachykinins+as+mediators+of+slow+EPSPs+in+guinea-pig+gall-bladder+ganglia%3A+involvement+of+neurokinin-3+receptors&rft.jtitle=The+Journal+of+physiology&rft.au=Mawe%2C+G+M&rft.date=1995-06-01&rft.issn=0022-3751&rft.eissn=1469-7793&rft.volume=485&rft.issue=2&rft.spage=513&rft.epage=524&rft_id=info:doi/10.1113%2Fjphysiol.1995.sp020747&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3751&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3751&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3751&client=summon |