Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

• Published in: Hepatology (Baltimore, Md.) Vol. 19; no. 6; p. 1400
• Main Authors: Martínez-Ansó, E, Castillo, J E, Díez, J, Medina, J F, Prieto, J
• Format: Journal Article
• Language: English
• Published: United States 01.06.1994
• Subjects: Amino Acid Sequence; Animals; Anion Transport Proteins; Antibodies, Monoclonal - immunology; Antiporters - analysis; Antiporters - chemistry; Antiporters - genetics; Antiporters - immunology; Bicarbonates - metabolism; Chloride-Bicarbonate Antiporters; Chlorides - metabolism; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Immunohistochemistry; Liver - chemistry; Liver - metabolism; Membrane Proteins - analysis; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - immunology; Mice; Molecular Sequence Data; SLC4A Proteins

Sodium-independent Cl-/HCO3- exchange activity has been observed in isolated rat hepatocytes and intrahepatic bile duct epithelial cells, where it is involved in intracellular pH regulation and, possibly, biliary bicarbonate secretion. Monoclonal antibodies to the membrane domain of human chloride/b...